Amyotrophic lateral sclerosis
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Structure based pharmacophore Modelling of compounds against Neurodegenerative disorder – Amyotrophic Lateral sclerosis
Abstract: Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by the progressive degeneration of motor neurons, leading to muscle dysfunction, paralysis, and eventually death. These diseases are classified as ALS variations because autopsies reveal abnormalities in both upper and lower motor neurons. These disorders account for only 10% of all adult-onset motor neuron disease cases. Despite extensive research efforts, effective therapeutic interventions for ALS remain limited. Structure-based pharmacophore modeling …
Published in Research and Reviews : Journal of Computational Biology · Vol. 12, Issue 3, 2023 · pp. 1–17 Read article
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Dysarthria and Dysphagia in Amyotrophic Lateral Sclerosis: A Case Study
Abstract: Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease affecting the bulbar, limb and respiratory muscles. ALS is generally characterized by progressive degeneration of both upper motor neuron (UMN) and lower motor neuron (LMN) dysfunction leading to a ‘mixed’ spastic-flaccid dysarthria. To date, only a few studies have been published regarding the nature of speech characteristics and dysphagia during the developmental course of ALS. The present study highlighted …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 10, Issue 3, 2020 · pp. 12–19 Read article