6-diazo-5-oxo-L-norleucine
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Inhibition of Replication of Adenovirus by 6-diazo-5-oxo-L-norleucine (DON)
Abstract: Normal 0 false false false EN-US X-NONE X-NONE The antibiotic known as 6-diazo-5-oxo-L-norleucine (DON) inhibits the growth of several types of Gram-positive and Gram-negative bacteria. DON has also been demonstrated to inhibit the replication of poliovirus, respiratory syncytial virus, mumps, and herpes simplex virus in cultured eukaryotic cells. DON is an analogue of glutamine and inhibits the synthesis of glycoproteins and purine nucleotides in cells that are treated with the …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 6, Issue 3, 2016 · pp. 31–37 Read article
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Inhibition of Replication of T2 Bacteriophage in Escherichia coli by 6-diazo-5-oxo-L-norleucine (DON)
Abstract: 800x600 Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 The antibiotic known as 6-diazo-5-oxo-L-norleucine, DON, inhibits the growth of several types of Gram positive and Gram negative bacteria. It has also been demonstrated that DON inhibits the replication of poliovirus, respiratory syncytial virus, mumps and herpes simplex virus in cultured eukaryotic cells. At a concentration of 0.03 mM DON, the replication of Escherichia coli cells was inhibited by 11.0% …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 2, Issue 1, 2012 Read article