Patents on Gastroretentive Drug Delivery System: An Overview

Lokesh P. Kothari; Atishkumar S. Mundada

Abstract

Background: Conventional oral dosage forms have poor bioavailability and recurrent dosing of the drug is needed to maintain the effective therapeutic concentration in the body. It may lead to poor patient compliance and fluctuations in the plasma level of drug especially in the chronic diseases and disorders. Origin: In outlook of this, to enhance the efficiency and bioavailability of the drug, gastroretentive drug delivery system is developed which can prolong the release and hence action of the drug in the body. Objective: The present review focus on recent patents and patent applications on gastroretentive drug delivery system. The various free patent search databases were used to collect and analyze the information on this oral drug delivery system. Results: Gastroretentive drug delivery system has been found to be of great importance due to their advantages over other oral dosage forms. These systems are formulated using various approaches and different types of release controlling polymers such as natural, semisynthetic, and synthetic polymers, and found to avoid the limitations of conventional oral dosage forms. Conclusion: Gastroretentive drug delivery system has potential especially in case of the chronic diseases and lifestyle disorders. These systems have unique commercial advantages which will sustain the interest of both the researchers and the pharmaceutical companies.

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