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2 articles for “PTP-1B”

• Published Subscription 17 May 2019

  Protein-Tyrosine Phosphatase-1B (PTP-1B) Inhibitory Perspectives of Hydroxylated Chalcones: Exploration through Docking Studies

  By SANTOSH S CHHAJED, NEHA A SALUNKE, Animeshchandra G M Haldar, Kanhaiya M Dadure, DEBARSHI KAR MAHAPATRA

  Abstract: The current research emphasized on exploring the Protein-Tyrosine Phosphatase-1 B (PTP-1B) inhibitory potentials of hydroxylated chalcone derivatives against PDB ID: 4I8N (PTP-1B in complex with an inhibitor [(4-{(2s)-2-(1,3-benzoxazol-2-yl)-2-[(4-fluorophenyl)sulfamoyl]ethyl}phenyl)amino](oxo)acetic acid) by molecular docking approach using the iGEMDOCK (Genetic Evolutionary Method for Molecular Docking) software. The current molecular docking analysis of some hydroxylated chalcone derivatives have presented a profound inhibition of the antidiabetic target PTP-1B by interacting with the amino acid residues …

  Published in Research & Reviews: A Journal of Bioinformatics · Vol. 6, Issue 1, 2019 · pp. 4–8 Read article →

• Published Subscription 7 Mar 2018

  Computational Identification of Protein Tyrosine Phospatase-1B (PTP-1B) Inhibitors for Checking Type II Diabetes

  By Dhirendra Kumar Bharti, Kamal Kumar Chaudhary, Sarvesh Kumar Gupta, Nidhi Mishra

  Abstract: Protein tyrosine phosphatases (PTPs) are a family of enzyme that comprises of about 100 proteins which catalyze dephosphorylation of phosphotyrosine residues in protein substrates. Phosphotyrosine is a central element in cell signaling, and its activity is essential for cellular homeostasis and for appropriate responses to extracellular signals. PTP-1B antagonizes insulin signaling by reducing the activation state of the insulin receptor kinase, thereby inhibiting post-receptor signaling in insulin responsive tissue. The …

  Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 6, Issue 3, 2017 · pp. 21–25 Read article →