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2 articles for “PROTACs”
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A Review on Targeted Protein Degradation and Its Novel Therapeutic Approaches
Abstract: A new concept of drug development is drug-induced degradation of a target protein. Protein degradation is one of the cell's methods for permanently inactivating proteins. The Ubiquitin-Proteasome System (UPS) and autophagy are two main intracellular protein degradation pathways in eukaryotes. Autophagy has been shown to be induced by inhibiting proteasomal activities, suggesting a coordinated and complementary relationship between these two mechanisms. However, little is known about autophagy's function in UPS …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 8, Issue 1, 2023 · pp. 12–23 Read article
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Identification of Elements Exist in Area Around Khartoum Petroleum Refinery Using Spectroscopic Method
Abstract: Laser-induced breakdown spectroscopy (LIBS) is a method of atomic emission spectroscopy (AES) that uses a laser-generated plasma as the hot vaporization, atomization, and excitation source. Plasma is often called the fourth state of matter. The various states of matter occur as a substance is heated to temperatures corresponding to thermal energies above the binding energies for particular state of matter. Structured systems placed in a sufficiently hot environment. LIBS technique …
Published in Journal of Petroleum Engineering & Technology · Vol. 12, Issue 1, 2022 · pp. 1–14 Read article