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3 articles for “OAS database”
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Integrative Structural-Functional Genomics of Fc and Fab: Precision Models for Monoclonal Antibody Stability and Anti-Aggregation Engineering
Abstract: Monoclonal antibodies (mAbs) represent the cornerstone of biotherapeutics, yet aggregation propensity compromises up to 50% of candidates during development, driven by Fab hypervariability and Fc vulnerabilities.(1,2) This review integrates functional genomics from OAS (4B+ sequences)(5) and structural databases (SAbDab: 10K+ structures)(6) with machine learning models achieving R=0.97 for SAP prediction.(11) We dissect biophysical mechanisms, benchmark predictive tools (DeepSP, ESM2), and engineering strategies (YTE, FW mutations) that enhance Tm by 5-10°C …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 1, 2026 Read article
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An Analysis of Open-Access E-Journals in Library and Information Science
Abstract: The growth of open-access e-journals in the field of Library and Information Science represents a transformative shift today. Open-access journals provide unrestricted access to peer-reviewed research, enabling Library and Information Science (LIS) professionals, researchers, and students worldwide to access required knowledge without subscription barriers. This study evaluates open-access (OA) e-journals in the field of LIS, assessing their accessibility, quality, and impact. Objectives: The main objectives of the study are to …
Published in Journal of Advancements in Library Sciences · Vol. 12, Issue 3, 2025 · pp. 39–56 Read article
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Quality Dimensions of Open Access E-Journals in Library and Information Science: An Analytical Study
Abstract: The rapid growth of open access e-journals in Library and Information Science marks a significant transformation today. Open access journals provide unrestricted access to peer-reviewed research, enabling LIS professionals, researchers, and students worldwide to access required knowledge without subscription barriers. This study focuses on evaluating open access (OA) e-journals in Library and Information Science (LIS), with particular attention to their accessibility, quality, and scholarly impact. The main objectives of the …
Published in Journal of Advancements in Library Sciences · Vol. 12, Issue 3, 2025 · pp. 52–68 Read article