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8 articles for “Motor Neurons”
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Dysarthria and Dysphagia in Amyotrophic Lateral Sclerosis: A Case Study
Abstract: Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease affecting the bulbar, limb and respiratory muscles. ALS is generally characterized by progressive degeneration of both upper motor neuron (UMN) and lower motor neuron (LMN) dysfunction leading to a ‘mixed’ spastic-flaccid dysarthria. To date, only a few studies have been published regarding the nature of speech characteristics and dysphagia during the developmental course of ALS. The present study highlighted …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 10, Issue 3, 2020 · pp. 12–19 Read article
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Structure based pharmacophore Modelling of compounds against Neurodegenerative disorder – Amyotrophic Lateral sclerosis
Abstract: Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by the progressive degeneration of motor neurons, leading to muscle dysfunction, paralysis, and eventually death. These diseases are classified as ALS variations because autopsies reveal abnormalities in both upper and lower motor neurons. These disorders account for only 10% of all adult-onset motor neuron disease cases. Despite extensive research efforts, effective therapeutic interventions for ALS remain limited. Structure-based pharmacophore modeling …
Published in Research and Reviews : Journal of Computational Biology · Vol. 12, Issue 3, 2023 · pp. 1–17 Read article
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A Review on Applications of Artificial Intelligence (AI) in Parkinsons’s Disease Diagnosis and Treatment and Its Future Challenges
Abstract: Parkinson’s disease (PD) is a long-term, progressive neurodegenerative disorder that mainly occurs in people older than 60 years, affecting nearly 1% of this population. It is chiefly marked by the loss of dopaminergic neurons in the substantia nigra, a crucial brain region responsible for controlling motor functions. The resultant dopamine deficiency significantly disrupts motor control, manifesting in clinical symptoms such as tremors, bradykinesia, muscle rigidity, and postural instability. While PD …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 15, Issue 3, 2025 · pp. 1–15 Read article
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Unraveling the Nexus: Parkinson's Disease, Alpha-synuclein, Desulfovibrio, and the Gut Microbiome
Abstract: Parkinson's disease (PD) is now recognized as a chronic condition which is once considered a highly intricate disorder involving the central, autonomic, and enteric nervous systems. The prevailing perspective attributes the disease by the formation of Lewy bodies, primarily triggered by the misfolding of α-Synuclein, leading to the demise of dopaminergic neurons in the substantia nigra. Constipation, one of the most common non-motor symptoms in PD patients, is believed to …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 2, Issue 1, 2024 · pp. 18–28 Read article
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Exploring the Complexities of Parkinson’s Disease
Abstract: Parkinson’s disease (PD) is a neurological disorder, primarily affecting older adults, marked by both motor and non-motor symptoms. This review explores PD as a multisystem disorder that influences the central, enteric, and autonomic nervous systems, along with the immune system and gastrointestinal tract. Key pathogenic features include the degeneration of dopamine-producing neurons in the substantia nigra and the formation of Lewy bodies containing misfolded α-synuclein proteins. The bradykinesia, tremors, stiffness, …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 14, Issue 3, 2024 · pp. 1–8 Read article
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Effect of Transcranial Direct Current Stimulation (tDCS) in Somatosensory Evoked Potential (SSEP) in Normal Adolescents
Abstract: tDCS is a noninvasive brain stimulation technique in which a mild electrical direct current is applied through the scalp to send electrical impulses to the brain to increase or decrease the excitability in the neurons. Weak transcranial direct current stimulation can induce long lasting changes in cortical excitability. The electrodiagnostic approaches like Motor Evoked Potentials (MEP), Somato Sensory Evoked Potential (SSEP) and electromyography are used to measure the effect of …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 3, Issue 2, 2013 · pp. 1–8 Read article
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Improvement of Motor and Sensory–Motor Behaviors after the Human Amniotic Epithelial Cells Transplantation in 6-OHDA Lesioned Corpus Striatum of Wistar Albino Rats
Abstract: Deficits in apomorphine-induced rotation and rotarod in rat have been proposed as a nondrug-induced model of the akinesia associated with the Parkinson’s disease. In the present study, we examined the disabilities in the rotarod and apomorphine-induced rotations have been observed after the 6-hydroxydopamine-induced denervation in the striatum. These impaired activities have reversed after the Human Amniotic Epithelial (HAE) cells transplantation during long-term observation. The neuronal densities and diameter were reduced …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 4, Issue 2, 2014 · pp. 34–45 Read article
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Stem Cell Therapy for Hemorrhagic Stroke: A Single Case Study Report
Abstract: Stroke is the leading cause of morbidity and mortality worldwide. Stem cell therapy holds a great promise where transplanted cells can migrate at the site of injury and trigger regeneration of neurons that can lead to functional improvement. The present study was carried out to evaluate the effect of autologous bone marrow and allogeneic cord blood stem cell transplantation in hemorrhagic stroke patients. In the present case report, autologous bone …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 2, Issue 2, 2012 · pp. 22–26 Read article