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2 articles for “Lorke’s method”

• Published Subscription 8 Jan 2020

  Preliminary Phytochemical and Acute Toxicity Studies of Different Extracts of Guiera Senegalensis

  By Rasheed-Jada Hadiza, Abubakar Umar Suleiman

  Abstract: The leaf of Guiera senegalensis is used in the management of many diseases in Nigeria and many African countries, but the medial lethal doses (LD50) of its different extracts are not widely investigated. To evaluate the phytochemical constituents and acute toxicity indexes of aqueous, hexane, dichloromethane and methanol leaf extracts of G. senegalensis, basic phytochemical screening methods were applied. While up and down procedure and Lorke’s method was used for …

  Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 6, Issue 3, 2019 · pp. 11–16 Read article →

• Published Subscription 12 May 2020

  Phytochemical, Acute Toxicity and Heavy Metals Evaluation of Khaya senegalensis (Desr.) A. Juss (Meliaceae) Stem Bark

  By A. Ali, Abubakar U.S., Suleiman A., Adeleke A.G., Abdulrazak A., Sa’adatu A.U.

  Abstract: The present work was aimed to determine the phytochemical constituents, median lethal dose (LD50) and levels of heavy metals in Khaya senegalensis stem bark obtained from Kano State, Nigeria. The preliminary phytochemical screening revealed the presence of steroids, terpenoids, alkaloids, anthraquinones, saponins, phenolic compounds and carbohydrates, while the LD50 of the aqueous stem bark extract was above 5000 mg/kg body weight using OECD and Lorke’s method. The heavy metals analysis …

  Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 7, Issue 1, 2020 · pp. 1–7 Read article →