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4 articles for “Long-acting injectables”
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Formulation Challenges in Long-acting Injectable Small Molecules: Emerging Strategies and Perspectives
Abstract: Long-acting injectable (LAI) formulations represent a transformative approach in pharmacotherapy, particularly for conditions demanding sustained drug exposure over weeks to months. Although biologics have dominated this space historically, the adaptation of LAI technology to small molecules presents a distinct and complex set of challenges rooted in physicochemical properties, manufacturing scalability, and regulatory expectations. This review systematically addresses the principal formulation barriers encountered in developing LAI small-molecule products, including aqueous solubility …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 2, 2026 Read article
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An AAV Vector for Inducible Gene Expression Preferentially in Muscles
Abstract: Adeno associated viral (AAV) vectors has been used widely in gene therapy and efforts have been made to improve their utility by adding genetic elements that would enable targeting transgene expression to particular cells or tissues of interest and permitting on/off regulation of expression. In this study, we designed a recombinant AAV9 variant PHP.eB vector with muscle creatine kinase (Mck)-derived enhancers, a synthetic muscle-expression promoter, in combination with a third-generation …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 1, Issue 2, 2023 · pp. 46–61 Read article
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An Automated Smart Contract Repair Framework for Reentrancy, Integer Overflow, and Denial- of-Service Vulnerabilities
Abstract: This paper introduces a novel static analysis framework designed to bridge a long-standing gap in Ethereum smart contract security: the disconnect between vulnerability detection and automated remediation. Although widely adopted tools such as Slither and Oyente are highly effective at identifying security weaknesses, they stop short of providing actionable fixes. As a result, developers manually patch vulnerabilities, a process that is not only time-consuming but also susceptible to human error …
Published in Journal of Computer Technology & Applications · Vol. 17, Issue 1, 2026 · pp. 31–41 Read article
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AI-Based Machine Learning Web Application Firewall (ML-WAF)
Abstract: This research investigates the use of deep learning techniques for the real-time detection of malicious activities in web traffic and proposes an intelligent, AI-driven Web Application Firewall (WAF) designed to provide automated and adaptive security. The system analyzes diverse components of HTTP requests, including request methods, URLs, headers, cookies, and payload content, to accurately identify and classify malicious behavior. The proposed model targets a wide range of common and critical …
Published in Journal of Computer Technology & Applications · Vol. 17, Issue 1, 2026 Read article