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1 article for “Aldose Reductase”

• Published Subscription 27 May 2019

  Hydroxylated Chalcone Derivatives as Future Aldose Reductase Inhibitors: Discovery through Docking Technique

  By Santosh S. Chhajed, Neha A. Salunke, Animeshchandra G.M. Haldar, Kanhaiya M. Dadure, Debarshi Kar Mahapatra

  Abstract: The research endeavors molecular docking assisted exploration of ALR inhibitory perspectives of some B-ring substituted hydroxyl group (A-ring) containing chalcone compounds against human aldose reductase in complex with NADP+ and the inhibitor IDD594 (PDB ID: 1US0) by utilizing the iGEMDOCK (Genetic Evolutionary Method for Molecular Docking) software. The present investigation immensely focused on the human aldose reductase inhibitory perspectives of some hydroxylated chalcone compounds. The inhibition of the enzyme by …

  Published in Research and Reviews : Journal of Computational Biology · Vol. 8, Issue 1, 2019 · pp. 8–12 Read article →