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4 articles for “AAV”
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An AAV Vector for Inducible Gene Expression Preferentially in Muscles
Abstract: Adeno associated viral (AAV) vectors has been used widely in gene therapy and efforts have been made to improve their utility by adding genetic elements that would enable targeting transgene expression to particular cells or tissues of interest and permitting on/off regulation of expression. In this study, we designed a recombinant AAV9 variant PHP.eB vector with muscle creatine kinase (Mck)-derived enhancers, a synthetic muscle-expression promoter, in combination with a third-generation …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 1, Issue 2, 2023 · pp. 46–61 Read article
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AI-Driven Home Security System
Abstract: The fast-paced growth in Artificial Intelligence (AI) and computer vision technologies has created new opportunities in the realm of home security. This paper outlines a developed model of an AI-powered home security system that encompasses face recognition technology for accessing and conducting surveillance at a home in real time. The real time system is designed with advanced algorithms for facial recognition, allowing it to target authorized individuals and intruders from …
Published in Journal of Communication Engineering & Systems · Vol. 15, Issue 3, 2025 Read article
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CFD Analysis of a Bladeless Propelling Unit for the Drones
Abstract: Conventionally, unmanned aerial vehicles (UAVs) and autonomous aerial vehicles (AAVs) utilize bladed propellers to produce lift, altitude, and thrust for propulsion. Yet, these blades are susceptible to abrasion when they contact external surfaces, resulting in diminished operational efficiency over time. Our ongoing investigation introduces a pioneering approach by integrating bladeless propeller technology, drawing inspiration from Dyson’s Bladeless Fan Theory. This study seeks to address the wear-related shortcomings of conventional propeller …
Published in Recent Trends in Fluid Mechanics · Vol. 11, Issue 3, 2024 · pp. 37–46 Read article
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Advancing Gene Therapy: Next-Generation Viral Vector Engineering for Precision, Safety, and Scalability
Abstract: Gene therapy has emerged as a paradigm-shifting modality for the treatment of genetic disorders, malignancies, and rare diseases through the delivery of therapeutic nucleic acids aimed at correcting or modulating dysfunctional gene expression. Among the various delivery systems, viral vectors including adeno-associated viruses (AAVs), lentiviruses, adenoviruses, retroviruses, and herpes simplex viruses have proven indispensable owing to their high transduction efficiencies and adaptability. This review offers a comprehensive assessment of viral …
Published in International Journal of Virus Studies · Vol. 2, Issue 2, 2025 · pp. 37–55 Read article