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1978 articles for “phosphoinositol-3-kinase pathway” (ranking capped at the first 2,000 matches — narrow the search to see the rest)
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Triple Negative Breast Cancer—Pattern of Recurrence and Survival: A Single Institute Experience
Abstract: Triple negative breast cancer (TNBC) is a distinct biological entity and recent data shows it as a heterogeneous group with at least 6 subtypes with differences in clinical outcome.This study intends to analyze the prevalence, recurrence pattern and outcome of triple negative breast cancer in our patient cohort.We reviewed the outcomes of 244 consecutive triple negative non-metastatic breast cancer patients who were treated with a radical intent from Jan 2004 …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 6, Issue 3, 2017 · pp. 5–8 Read article
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Glutathione: Postoperative Study in Breast Carcinoma
Abstract: Breast cancer represents a significant problem in the world. Glutathione a tripeptide is found in all mammalian tissues. Thus any change in its synthesis or utilization can profoundly influence the redox status of cells. In this study blood sample was collected from 60 FNAC confirmed breast cancer patients (preoperative and postoperative three months) and 30 normal healthy controls for the estimation of glutathione. There was significant increase in glutathione in …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 7, Issue 1, 2018 · pp. 3–6 Read article
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Occult Follicular Carcinoma of Thyroid Presenting as Skull Bone Metastasis: A Rare Case Report
Abstract: Follicular thyroid carcinoma (FTC) is a well-differentiated tumor and second most common cancer of the thyroid after papillary carcinoma. They account for 5 to 15% of primary thyroid cancers. Most patient present with a thyroid swelling, only up to 11% patient present with distant metastasis. Skull is a rare site for metastasis. The incidence of skull metastasis of FTC is about 2.5% and, in most cases, metastasis occurred after the …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 7, Issue 3, 2018 · pp. 30–33 Read article
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The New Dimension of Cancer: It is Not a Disease but a Deficiency of Vitamin B17
Abstract: Most commonly used an alternative drug in the treatment of tumor in the last 40 years is Amygdalin. Treatment based on the use of Vitamin B-17, proteolytic pancreatic enzymes, immunostimulants, vitamin and mineral supplements for cancer is a metabolic therapy which is nontoxic. National Cancer Institute is unsuccessful to prove that Laetrile is ineffective and toxic during their studies by clinical trials in 1981. Today, position on the "front lines" …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 7, Issue 3, 2018 · pp. 34–36 Read article
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Determinants of Survival among Hemodialysis Patients at Ayder Comprehensive Specialized Hospital, Tigray, North Ethiopia: A Retrospective Cohort Study
Abstract: Background: Chronic kidney disease is a common public health problem with increase the incidence and prevalence, which nearly doubled as a cause of death worldwide. However, the access to care and knowledge about the predictors of survival among hemodialysis patients is extremely limited in Ethiopia. The aim of this study is, therefore, to identify predictors of survival among hemodialysis patients. Methods: A retrospective cohort study was conducted by reviewing records …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 7, Issue 3, 2018 · pp. 22–29 Read article
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Pattern of Care and Pattern of Survival Study in ca Cervix: Implications of a Published Study
Abstract: This article is being written in the context of the recently published multi-institutional study of POSCC for patients of cervical cancer in India. This study involves both private and public funded institutions and has hospitals from most parts of the country. This study is of utmost relevance in current day India, since India alone accounts for one-fourth of the total burden of disease. Stage I cervical cancer has a fairly …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 4, Issue 3, 2015 · pp. 14–18 Read article
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Explore the Level of Awareness, Perception and Utilization of Pressure Ulcer Prevention among Health Professionals, Ayder Referral Hospital, 2013
Abstract: Pressure ulcer can have a major impact on both the individual and health care system and produce a significant burden on patients, relatives and caregivers like that of increased distress, increased pain, unable to return to normal life functions, reduced quality of life, increased risk of infections, increased mortality risk etc. The objective of the study was to determine the level awareness, perception and practice towards pressure ulcer prevention among …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 5, Issue 1, 2016 · pp. 24–29 Read article
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Practice of Breast Self-Examination among Female Health Care Professionals in Maichew Town Health Facilities, Tigray, Ethiopia: Institution Based Cross-Sectional Study
Abstract: Breast cancer is among the major life-threatening public health concerns and its incidence is increasing worldwide. Breast self-exam (BSE) is commendation for all women starting in their 20s to know how their breasts normally look and feel like and to notice any changes occur. They should be told about its benefits and limitations too. It is an important procedure in the early detection of breast cancer. It is estimated that …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 5, Issue 1, 2016 · pp. 30–37 Read article
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Knowledge and Skill of Staff Nurses Regarding Breast Cancer and Breast Self-Examination
Abstract: Breast cancer comprises about 25% of all female cancers. Its incidence is rising constantly, also among younger women. Every 15 min, three breast cancer cases are diagnosed and one woman dies of this disease. Breast cancer is the leading cause of death among women in the age group of 40–44 years and the incidence increases significantly after 50. This experimental pre-test post-test control group design aims to evaluate the effectiveness …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 5, Issue 2, 2016 · pp. 1–5 Read article
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Role of Radiation Therapy in the Management of Mycosis Fungoides
Abstract: Cutaneous T-cell lymphoma (CTCL) consists of spectrum of diseases of which Mycosis Fungoides and Sézary's syndrome are most common. Mycosis Fungoides (MF) is a low-grade, chronic lymphoproliferative disorder affecting skin caused by abnormal proliferation of CD4 + T-cells. The incidence of MF is showing an increasing trend all over the world. Also, it is seen twice as often in males as in females (2:1) and mostly it occurs after fourth …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 1, Issue 1, 2012 · pp. 6–15 Read article
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Chemotherapy: Side Effect and Management
Abstract: Cytotoxic drugs are therapeutic agents intended for but not constrained to, the treatment of cancer. These drugs are kenned to be highly toxic to cells, mainly through their action on cell reproduction. Cytotoxic drugs are increasingly being utilized in a variety of health care settings, laboratories and veterinary clinics for the treatment of cancer and other medical conditions such as rheumatoid arthritis, multiple sclerosis are autoimmune disorders. Cytotoxic drugs are …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 5, Issue 3, 2016 · pp. 30–40 Read article
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Ewing’s Sarcoma (ES): A Single Centre Retrospective Study
Abstract: The treatment of Ewing’s sarcoma (ES), which is thought to be derived from primitive mesenchymal cells, involves chemotherapy, surgery and radiotherapy. While there is ample data in the world literature showing drastic changes in outcome of this disease, prognosis in Indian patients is largely unknown due to dearth of studies in our setting. The objective of the present study was to study the clinical, pathologic, cytogenetic profile and outcome of …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 2, Issue 2, 2013 · pp. 1–7 Read article
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Uranium Content Anomalies in Groundwaters of Fazilka District of Punjab (India) for the Assessment of Excess Cancer Risk
Abstract: Inductively coupled plasma mass spectroscopy (ICPMS) has been used to measure the uranium content of the ground water samples of Fazilka district of Malwa belt of Punjab (India). Out of total 217 habitations having more than 60 ppb of uranium (safe limit of AERB for India), 30 have been selected for the present investigation. The aim of this study is to investigate the uranium content of the ground water in …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 6, Issue 2, 2017 · pp. 21–26 Read article
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Clinicopathological Study of Oral Malignant and Premalignant Lesions with p53 and p16 Immunostaining
Abstract: Oral cancer is a global problem, more in India. A study of 50 cases of oral lesions were conducted in a tertiary care hospital in Kolkata, India. Detailed clinical history was taken. Cytology, punch biopsy with histopathology and immunostaining with p53 and p16 were done in all the cases. A total of 31 cases (62.0%) were benign, 19 cases (38.0%) were malignant, with an age range of 26–69 years (mean …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 8, Issue 2, 2019 · pp. 20–24 Read article
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To Develop Self-instructional Module on ‘Umbilical Cord Stem Cell Collection, Preservation and Utilization’ and Evaluate its Effectiveness on Improving the Knowledge of Operational Level Nurses
Abstract: Umbilical cord stem cell based regenerative and cellular medicine has now become a fascination for all. The umbilical cord blood, donated by mothers after the birth of newborn, has become an accepted source of hematopoietic stem cells for bone marrow reconstitution. They play an important role in the treatment of blood and immune system related genetic diseases, cancers, and blood disorders. This study is aimed to assess the knowledge of …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 9, Issue 3, 2020 · pp. 10–22 Read article
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Nitrosamine: The Carcinogenic Impurity in Angiotensin Receptor Blockers
Abstract: Angiotensin II Receptor Blockers (ARBs), commonly known as the Sartans, are used in the treatment of hypertension for a long time. Currently, seven Sartan drugs, i.e. Valsartan, Losartan, Candesartan, Irbesartan, Telmisartan, Olmesartan, and Eprosartan, are in use. Recently, Nitroso impurity was detected in Valsartan active pharmaceutical ingredient, which led to the recall of batches of products containing it. Even in trace amounts, the impurity is said to be a probable …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 9, Issue 3, 2020 · pp. 36–43 Read article
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The Effect of the 632.8 nm Laser Blood Irradiation on PASI, TC and TG in Patients with Psoriasis Vulgaris
Abstract: Objectives: The aim of this study is to study the effect of the 632.8nm laser blood irradiation (LBI) on PASI, TC and TG in patients with psoriasis vulgaris. Patients and methods: A total of 90 cases of psoriasis vulgaris were divided into 3 groups according to the paths of laser irradiation: Intravenous Laser Blood Irradiation (ILBI: A Group), nasal mucous irradiation (B Group), no irradiation (C Group). All patients were …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 9, Issue 3, 2020 · pp. 44–46 Read article
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Study to evaluate the efficacy of video-assisted educational strategies in managing chemotherapy side effects among cancer carers in the home environment at the Regional Cancer Centre, Agartala.
Abstract: Introduction and study objectives: The quasi-experimental study examined how video- assisted instruction affected cancer patients at Regional Cancer Centre of Agartala understanding of chemotherapy side effects and coping techniques. Cancer education will help patients cope with challenges and increase self-management, improving quality of life. At Regional Cancer Centre of Agartala, the investigator tested a video-assisted instruction curriculum on chemotherapy side effects at home for cancer carers. Study objectives are as: …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 12, Issue 3, 2023 · pp. 1–12 Read article