Search
142 articles for “Inhibitory”
-
Antidiabetic Activity of Triazole Derivatives: A Review
Abstract: Triazoles are the most commonly synthesized nitrogen containing hetero cyclic compounds which have a numerous biological activity viz. antifungal, antimicrobial, anthelmintic, anticancer, anti-tubercular and antiviral activities. They are 5-membered hetero ring structure containing nitrogen as heteroatom at 3 positions. Over a decade, studies are being focused on the anti-diabetic activity of 1,2,3-triazole and 1,2,4-triazole derivatives. Diabetes mellitus is a disorder in which the body doesn't produce enough insulin or does …
Published in Trends in Drug Delivery · Vol. 9, Issue 1, 2022 · pp. 1–20 Read article
-
Molecular Docking Technique Assisted Discovery of Some Hydroxylated Chalcone Molecules as α-glucosidase Inhibitors
Abstract: The present study involved exploration of the inhibitory potential of some A-ring hydroxylated chalcone compounds against PDB ID: 2QMJ file (Maltase-glucoamylase in complex with acarbose) with the assistance of iGEMDOCK (Genetic Evolutionary Method for Molecular Docking) software. The present study highlighted the immense potentials of several unexplored hydroxyl group (in ring-A) containing chalcones in successfully inhibiting the one of the most effective anti-hyperglycemic based enzymatic target α-glucosidase. The research has …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 6, Issue 1, 2019 · pp. 34–38 Read article