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183 articles for “Protein-protein interactions”
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The Interaction of Extracellular Matrix and Growth Factors
Abstract: The extracellular matrix (ECM) regulates cell behavior by influencing cell proliferation, survival, shape, migration and differentiation. ECM assembly is regulated by the 3D environment and the cellular tension that is transmitted through integrins. The hematopoietic microenvironment is a complex structure in which stem cells, progenitor cells, stromal cells, growth factors, and ECM molecules each interact to direct the coordinated regulation of blood cell development. Hematopoietic growth factors are any of …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 6, Issue 3, 2016 · pp. 9–23 Read article
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Exploring Phytochemicals from Ricinus Communis for Potential Therapeutic Applications in Rheumatoid Arthritis: An in-Silico Approach
Abstract: Aim: Rheumatoid arthritis (RA) is a long-term autoimmune condition characterized by the immune system mistakenly attacking the joints, leading to swelling, discomfort, and joint deformities. Current management strategies include anti-rheumatic drugs and biologics, which have limitations. This study aims to explore the therapeutic potential of Ricinus communis (castor bean plant) phytochemicals as plant-based therapies for autoimmune conditions, like RA. Methods: Phytochemicals from Ricinus communis were retrieved using the IMPPAT database, …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 1, 2025 · pp. 32–41 Read article
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Epitope-Based Peptide Vaccine Design Against Nuclear Protein EBNA3C of Epstein-Barr Virus: An Approach to Treat Multiple Sclerosis
Abstract: Almost 95% of the world’s population is affected by the Epstein-Barr virus (EBV); it is an oncogenic virus of herpes virus family. The nuclear protein Epstein-Barr nuclear antigens (EBNA)-3C of EBV are related to multiple sclerosis (MS) which is an inflammatory disease of the nervous system. Regardless of multiple occurrences of infections due to EBV and shortage of licensed antiviral drugs, there is not much advancement on vaccine designed for …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 9, Issue 1, 2019 · pp. 62–72 Read article
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Current Drugs Target the EGFR
Abstract: Cancer is a devastating disease, but there have recently been significant advancements in therapy that have identified EGFR and its related proteins as valuable indicators and targets for treatment. The ERBB receptor tyrosine kinase superfamily includes EGFR, which is a transmembrane glycoprotein. When the EGFR receptor interacts to its particular ligand, EGF, it causes tyrosine residues to be phosphorylated and forms receptor dimers with other members of the receptor family. …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 13, Issue 2, 2024 · pp. 1–8 Read article
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Carbon Nanotubes: Revolutionizing Noval Drug Delivery Approach for Alzheimer's Disease
Abstract: The objective of the review was to comprehensively study the application of nanotechnology and investigate the potential of carbon nanotubes in serving as a drug delivery system to improve the condition of Alzheimer's disease. Alzheimer's disease, characterized as an irreversible and progressive cerebral disorder, presents clinical manifestations such as dementia, cognitive decline, altered personality, impaired motor function, confusion, and diminished cognitive planning. The neurodegenerative processes inherent in Alzheimer's disease stem …
Published in Trends in Drug Delivery · Vol. 10, Issue 3, 2023 · pp. 10–15 Read article
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Interaction of Mosquito’s hppd Enzyme with Lansoprazole Sulfide A New Hope to Tackle the Mosquito Menace – an in-Silico Study
Abstract: Tyrosine detoxification is an important physiological process that helps blood-feeding insects, such as mosquitoes that transmit Plasmodium parasites causing malaria, digest their blood meals. An enzyme known as 4-hydroxyphenylpyruvate dioxygenase (HPPD), which is part of the tyrosine detoxification pathway, helps in removing excess tyrosine in a high-protein blood meal. Excess tyrosine can be lethal to the insects, and hence, the role of HPPD enzyme is very critical. Inhibitors of HPPD …
Published in International Journal of Insects · Vol. 3, Issue 1, 2026 · pp. 1–11 Read article
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Effect of Nitrogen Fertilizer Levels on Malt Quality Parameters of Malt Barley (Hordeum vulgare L.) Varieties at Kulumsa, Central Ethiopia
Abstract: AbstractA field experiment was conducted at Kulumsa agricultural research center during 2011 main season with the objectives of determining the effect of different nitrogen fertilizer levels on malt quality of common malt barley varieties. Factorial combinations of four released malt barley varieties namely, ‘Beka’, ‘Holker’, ‘Miscal-21’ and ‘EH1293’ and five levels of nitrogen fertilizer (0, 20, 30, 40 and 50 kg N/ha) in the form of urea (46% N) were …
Published in Research and Reviews : Journal of Crop science and Technology · Vol. 4, Issue 3, 2015 · pp. 33–45 Read article
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In Silico Analysis and Docking Study of the Active Phyto Compounds of Ginkgo Biloba Against Alzheimer's Amyloid-Beta Protein
Abstract: Objective: Alzheimer's disease, an age-related progressive neurological condition, arises due to the accumulation of amyloid-beta protein within the brain. In this study, an attempt was made to explore the potential of natural compounds derived from Ginkgo, known for their diverse medicinal properties, in the prevention of the disorder by employing molecular docking techniques, conducting drug-likeness prediction assessments, and performing ADME analysis. Methods: Amyloid beta protein was retrieved from the PDB …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 2, 2023 · pp. 17–30 Read article
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INVESTIGATING PHYTOCHEMICAL INHIBITORS OF PSEUDOMONAS AERUGINOSA'S AHL SYNTHASE LASI: A PATH TOWARD NOVEL THERAPEUTIC AGENTS
Abstract: Objectives: This study intended to explore the potential of phytochemicals from Allium sativum to inhibit AHL synthase LasI, a critical protein of the Quorum Sensing (QS) pathway in Pseudomonas aeruginosa, with the ultimate objective of developing therapeutic agents for managing P. aeruginosa infections. Methods: The physicochemical properties, toxicity, aggregation ability and binding potential of phytochemicals from Allium sativum to the protein AHL synthase LasI were determined. Physicochemical properties, toxicity and …
Published in Research and Reviews : Journal of Computational Biology · Vol. 12, Issue 3, 2023 · pp. 40–54 Read article
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Review on Morinda citrifolia L.—Noni Juice
Abstract: Noni juice is a globally popular health beverage originating in the tropics and used since long in traditional medicines in certain areas around the globe. A review published that noni juice may provide protection against tobacco smoke-induced DNA damage, blood lipid and homocysteine elevation as well as systemic inflammation. Morinda citrifolia contains phytochemicals that own antibacterial, antiviral, antifungal, antitumor, anthelminthic, analgesic, hypotensive, anti-inflammatory, immune enhancing effects, improve joint health, increase …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 7, Issue 1, 2020 · pp. 55–60 Read article
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Nutrient Sensing and Microbiota Crosstalk: Driving Determinants Shaping Metabolic Stability and Adaptive Physiology for Animal Health
Abstract: Nutrient sensing is a fundamental cellular process that enables animals to adapt to fluctuating dietary inputs while maintaining metabolic homeostasis and health. Recent advances reveal that the gut microbiota functions as an active metabolic partner, producing bioactive metabolites that directly influence host nutrient-sensing pathways and downstream cellular responses. This review synthesizes current knowledge on the integration of key signalling networks, including adenosine monophosphate activated protein kinase (AMPK), mechanistic target of …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 2, 2026 Read article
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Effect of Sulphur and Zinc Levels on Growth, Yield and Quality of Mustard [Brassica juncea (L.) Czern & Coss.]
Abstract: The experiment was conducted at Agronomy Research Farm of Narendra Deva University of Agriculture and Technology, Faizabad (Uttar Pradesh), during the rabi season of 2008-09 in RBD and replicated three times. The sowing was done on November 20, 2008. The treatments comprised four levels of sulphur (0, 20, 40 and 60 kg S ha−1) and four levels of zinc (0, 5, 7.5 and 10 kg Zn ha−1). The mustard variety …
Published in Research and Reviews : Journal of Crop science and Technology · Vol. 2, Issue 1, 2013 · pp. 1–10 Read article
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Effect of Energy/Protein Ratio and Strain on Performance, Nutrient Digestibility and Serum Biochemical Indices of Exotic and Locally Adapted Turkey
Abstract: This study investigated the response of locally adapted and exotic turkeys raised under the same environmental conditions to diets with varying energy/protein ratio. One hundred and fourty-four (144) four-week old poults of each strain of turkey were randomly selected and assigned to six different diets in a 2 x 2 x 3 factorial arrangement. Each treatment diet were replicated twice with twelve (12) birds per replicate. Diets formulated with 28 …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 1, Issue 2, 2023 · pp. 37–45 Read article
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A Molecular Docking Study: Targetting HIV-1 Integrase Protein Against Selected Phytocompounds from Calophyllum Lanigerum
Abstract: Objectives: The most common form of HIV that causes AIDS is HIV-1. The World Health Organization has estimated roughly 75 million plus HIV-1 infections till date and roughly 40 million deaths (as of 2021). Thus, this study was done to identify natural compounds from Calophyllum lanigerum, a medicinal plant largely endemic to South-East Asia, to inhibit the spread of this disease. It did so by using molecular docking methods, Lipinski …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 2, 2023 · pp. 43–55 Read article
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Optimizing Grazing Systems for Promoting Early Puberty in Dairy Heifers: An Integrated Nutritional Perspective
Abstract: The onset of puberty in dairy heifers is a critical milestone in ensuring optimal reproductive performance and overall herd productivity. Grazing systems, when strategically managed, may play a significant role in accelerating puberty through their influence on nutritional intake and heifer management practices. This review explores the impact of different grazing systems on the nutritional status of dairy heifers, emphasizing the balance between nutrient supply and demand during critical growth …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 4, Issue 1, 2026 Read article
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The Principles and Applications of Structural Symmetry in Natural and Engineered Systems: A Comprehensive Review
Abstract: Structural symmetry is a fundamental constraint across scientific domains, dictating the stability, functionality, and efficiency of systems from the subatomic to the macroscopic. In physics and chemistry, symmetry is mathematically defined through Group Theory, specifically point groups (e.g., Cnv, Oh). These groups govern molecular orbital interactions; high-symmetry configurations, such as the icosahedral C60 fullerene, achieve optimal energy distribution and structural resilience. In Structural Biology, symmetry is an evolutionary strategy for …
Published in Emerging Trends in Symmetry · Vol. 2, Issue 1, 2026 · pp. 30–34 Read article
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Enhancing Puberty in Dairy Heifers: Targeted Management Practices For Sustainable Development.
Abstract: Early attainment of puberty in dairy heifers is critical for improving reproductive efficiency and ensuring sustainable dairy production systems. This study explores targeted management practices that can accelerate puberty onset, contributing to enhanced productivity and economic viability in dairy farming. Key factors influencing puberty in heifers include nutritional management, genetic potential, health care, environmental factors, and behavioral interventions. Adequate nutrient supply, especially energy and protein, along with balanced mineral and …
Published in Research & Reviews : Journal of Ecology · Vol. 14, Issue 2, 2025 · pp. 28–35 Read article
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An Integrated Study to Extrapolate the Interaction of NMDAR with Potential Ligands for the Treatment of Alzheimer’s Disease Symptoms
Abstract: Objective: Alzheimer’s disease (AD) is the most common neurodegenerative disease affecting the health status of older adults especially those above the age of 60 years. As an outcome, two types of medications have been developed for the treatment of its symptoms which are acetylcholinesterase (AChE) and N-methyl-D-aspartate receptor (NMDAR) antagonist. This paper uses the computational approach to understand the interaction of NMDAR with four major phytocompounds (curcumin, L-epicatechin, ginsenosides, and …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 1, Issue 1, 2023 · pp. 15–27 Read article
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Molecular Dynamics and Therapeutic Architectures of Cannabinoid Receptors: A Comprehensive Review
Abstract: Expanding on these foundations, recent structural biology studies using cryo-electron microscopy have provided high-resolution insights into the conformational dynamics of CB₁ and CB₂ receptors. These findings have enabled a more precise understanding of ligand–receptor interactions, particularly how agonists, antagonists, and reverse agonists stabilize distinct receptor states. Such knowledge is critical for rational drug design, allowing researchers to selectively modulate downstream signaling pathways. For instance, CB₁ receptors primarily couple to Gi/o …
Published in International Journal of Cheminformatics · Vol. 4, Issue 1, 2026 · pp. 36–40 Read article
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Pharmacodynamics and Drug–Receptor Interactions: Integrating PK/PD Modeling with Modern Drug Development
Abstract: Understanding drug action requires an integrated perspective of pharmacodynamics and pharmacokinetics, which together determine therapeutic efficacy and safety. This review provides a comprehensive overview of the mechanisms underlying drug action, with particular emphasis on drug–receptor interactions and their role in modulating physiological responses. Drugs exert their effects primarily through interactions with specific biological targets, including receptors, enzymes, ion channels, and transporters, resulting in a spectrum of desired and adverse outcomes. …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 2, 2026 · pp. 33–47 Read article