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412 articles for “PKA/CREB pathway”
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Advancements in Antiviral Therapeutics: Strategies and Challenges in the Development of Drugs and Vaccines for Viral Diseases
Abstract: Viral infections continue to pose a significant threat to global health, leading to high rates of illness, death, and economic burden. The constantly evolving nature of viruses, along with the rise of drug-resistant strains, underscores the need for continuous advancements in antiviral treatments. This review highlights the pivotal role of antiviral drugs and vaccines in mitigating the impact of viral infections, showcasing recent breakthroughs and exploring emerging technologies. Key advancements …
Published in International Journal of Virus Studies · Vol. 1, Issue 1, 2024 · pp. 32–36 Read article
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Exploring the Pathophysiology of Henoch-Schönlein Purpura (HSP): A Comprehensive Review
Abstract: Blood from tiny veins can leak into nearby tissues, causing purpura, a disorder marked by red spots or patches on the skin that may have an impact on the kidneys. Henoch-Schönlein purpura (HSP) is associated with vasculitis and inflammation of blood vessels. The range of renal conditions associated with purpura includes severe glomerulonephritis and mild proteinuria. For instance, immunological complex accumulation in the renal glomeruli of HSP patients might result …
Published in International Journal of Cell Biology and Cellular Functions Read article
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Deciphering the Pathophysiology of Migraine: Understanding Trigeminovascular System Activity and the Importance of the Gut-Brain Axis
Abstract: Migraine, a prevalent and disabling neurological condition, manifests in distinct phases: premonitory, aura, headache, postdrome, and interictal. Being a primary contributor to adult disability, it presents a substantial economic challenge on a global scale. Even with extensive research spanning centuries, the complete grasp of its root causes continues to evade us. This intricate neurovascular disorder primarily involves local vasodilation of intracranial and extracerebral blood vessels, coupled with simultaneous stimulation of …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 1, 2024 · pp. 50–61 Read article
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The Impact of Climate Change on Infectious Diseases: Potential Risks and Mitigation Strategies
Abstract: As we confront the pressing challenge of climate change, it's vital to recognize its intertwined connection with infectious diseases. We must now navigate a future that combines strong public health interventions, environmental stewardship, and strong policy actions as we stand at the crossroads of crises. In an attempt to lessen the drastic effects of climate change on the dynamics of disease transmission, this study identifies potential risks and creative solutions. …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 13, Issue 2, 2024 · pp. 21–32 Read article
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Oxadiazole Derivatives Recent Progress in Synthesis and Bioactivity
Abstract: Over the past few decades, significant advancements have been made in the development of heterocyclic derivatives, leading to the production of numerous novel agents, both synthetic and natural in origin. Because of its numerous biological properties, including antibacterial, antiviral, and antifungal properties, thiazole is a special five-membered heterocyclic motif among heterocyclic compounds. It is utilized as a fundamental building block in many pharmaceutically significant compounds. To the best of our …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 15, Issue 1, 2024 · pp. 62–67 Read article
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A Surgical Exploration of the Mechanism and Regulation of the Respiratory System: A Conceptual Analysis
Abstract: The respiratory system plays a vital role in facilitating the movement of air in and out of the body, comprising a complex network of anatomical pathways. It is conventionally divided into two primary sections: the upper respiratory tract and the lower respiratory tract. Within the upper respiratory tract lie structures extending from the nasal passages down to the vocal cords, crucial for phonation. These vocal cords, composed of mucous membrane …
Published in Research and Reviews : Journal of Surgery · Vol. 13, Issue 1, 2024 · pp. 56–63 Read article
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In Situ Investigation of Hemidesmus indicus Phytocompound Extracts as a Therapeutic Target for Acute Myeloid Leukemia
Abstract: Objective: Acute myeloid leukemia (AML) is an apoptotic condition in the hematopoietic system induced by the differentiation and maturation of stem cells into erythrocytes, and leukemic cell proliferation is suppressed as the PI3K-Akt-mTOR pathway is pharmacologically targeted with certain inhibitors. As a result, in silico molecular docking of compounds against AML receptors, CTMP, was used in computational research on Hemidesmus indicus to uncover therapeutic phytochemicals for AML. Thus, this study …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 1, 2024 · pp. 38–53 Read article
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A Comparative Techno-economic Analysis of Hydrogen Production Processes from Locally Available Resources in Nigeria
Abstract: In this work we report result of techno-economic analyses of three hydrogen production pathways - Steam Methane Reforming (SMR), SMR with Carbon Capture (SMR+CC) and Proton Exchange Membrane electrolysis (PEM) – using integrated process-cost simulation-estimation methodologies. Process modeling and simulation is performed with Aspen Hysys® and Aspen Plus® (V10). Cost modeling and estimation is based on full lifecycle cost of production using the Levelized Cost of Hydrogen (LCOH) approach. Feedstock …
Published in Journal of Alternate Energy Sources & Technologies · Vol. 15, Issue 1, 2024 · pp. 29–46 Read article
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A Comprehensive Review of Biodegradable Polymers in Sustainable Packaging Applications
Abstract: The widespread use of synthetic plastics poses significant environmental challenges due to their durability and dependence on non-renewable resources. Biodegradable plastics, derived from renewable biological sources, offer a sustainable alternative that can mitigate waste disposal issues and environmental pollution. This paper examines the factors influencing the suitability of bioplastics for various packaging applications and discusses emerging techniques to enhance their properties. Regarding packaging applications in particular, biodegradable plastics offer a …
Published in Research & Reviews : Journal of Food Science & Technology · Vol. 13, Issue 1, 2024 · pp. 28–37 Read article
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Exploring Additive Manufacturing Technologies in Engineering: A Comprehensive Study
Abstract: The objective of this research was to systematically elucidate various pathways in casting, focusing on the utilization of Additive Manufacturing (AM) technology and its transformative impact on investment casting. The purpose of this systematic review is to ascertain whether AM may be a practical solution for investment casting production. Diverse databases, including Google Scholar, Research Gate, Mendeley, and Science Direct, were utilized for comprehensive research. When compared to creative techniques …
Published in International Journal of Machine Systems and Manufacturing Technology · Vol. 2, Issue 1, 2024 · pp. 16–19 Read article
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Enhancing ABET Summative Direct Assessment with AI and Blockchain: A Framework for Personalized Learning and Secure Evaluation
Abstract: Accreditation Board for Engineering and Technology (ABET) emphasizes the achievement of specific measurable learning outcomes. However, conventional assessment methods often find it challenging to accurately capture the complexities of student learning and program effectiveness within the ABET framework. This study proposes a novel framework that enhances ABET summative direct assessment by integrating a carefully structured, weighted assessment system with the transformative potential of artificial intelligence (AI) and blockchain technologies. The …
Published in International Journal of Algorithms Design and Analysis Review · Vol. 2, Issue 1, 2024 · pp. 28–42 Read article
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An in-silico toxicity study of the phytocompounds found in Pongamia pinnata leaves using the ProTox-II web server
Abstract: The aim of the current study was to determine the Insilco toxicity of the phytocompound present in the leaves of Pongamia pinnata. The leaves of Pongamia pinnata have long been used in traditional medicine for their therapeutic properties. Nowadays, herbal toxicity is a common problem caused by incorrect dosage. The FDA reviews the safety and effectiveness of herbal products only in response to patient or health care provider complaints—problems with …
Published in Research and Reviews : Journal of Crop science and Technology · Vol. 13, Issue 1, 2024 Read article
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Arabidopsis thaliana. (L.) Heynh Multifunctional Sensor Proteins and Signaling Networks Plant Photoreceptors
Abstract: Light is a crucial environmental cue for the growth and development of plants as well as the production of photosynthetic energy. In order to recognize and process information from incoming light, plants employ sophisticated mechanisms. With the model plant Arabidopsis thaliana, five different types of photoreceptors have been found. (L.) Heynh Photoreceptors play a specialized and/or recurring role in fine-tuning many aspects of the plant's life cycle. Unlike mobile animals, …
Published in International Journal of Photochemistry and Photochemical Research · Vol. 1, Issue 2, 2023 · pp. 08–24 Read article
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AIducate: Your Smart Tutor–A Survey
Abstract: The ongoing “datafication” of our social reality has led directly to the emergence of new data-driven business models across various sectors, including education. As a result, the market for educational services is rapidly expanding. Educational technology (EdTech) companies are at the forefront, offering data-driven pedagogical solutions that are reshaping the landscape of learning. Despite the market's growth, few companies are harnessing the full potential of artificial intelligence (AI) and machine …
Published in Journal of Multimedia Technology & Recent Advancements · Vol. 11, Issue 2, 2024 · pp. 25–30 Read article
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Change Detection in Aerial Imagery
Abstract: The development of the Multi U-Net engineering marks an essential headway in geospatial question location inside ethereal symbolism investigation. The altered U-Net addresses the complexities of multi-class division in assorted geospatial settings. Leveraging the inalienable growing and contracting pathways inside U-Net plans, the Multi U-Net exceeds expectations in capturing complicated spatial data, in this manner setting up a vigorous establishment for exact division. The extend envelops an advanced picture handling …
Published in Journal of Image Processing & Pattern Recognition Progress · Vol. 11, Issue 2, 2024 · pp. 22–28 Read article
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ISGylation: A Key Host Cellular Defense Mechanism
Abstract: ISGylation, a crucial process of the innate immune response, has garnered increasing attention for its involvement in host's defense against pathogenic infections as well in cancer progression. The key player of ISGylation, ISG15, is stimulated by type I interferons (IFNs). ISG15 covalently binds with viral (influenza NS1A and nucleoproteins) and host (Nedd4, filamin B and CHMP5) target proteins and this interaction inhibits the viral replication process and release of viral …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 14, Issue 2, 2024 · pp. 68–80 Read article
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Revolutionizing Material Flow and Handling: Industry 4.0 Integration in Logistics Management
Abstract: The integration of Industry 4.0 technologies has become pivotal in reshaping material flow and handling paradigms within logistics management. This paper presents an in-depth analysis of this transformative phenomenon. Industry 4.0's emergence has heralded an era of unprecedented automation, seamless data exchange, and cutting-edge technologies, fundamentally altering conventional logistics practices. Through an extensive review of recent literature, this study meticulously examines the profound impact of Industry 4.0 on material flow …
Published in International Journal of Advanced Robotics and Automation Technology · Vol. 2, Issue 1, 2024 · pp. 24–34 Read article
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Integrating Network Pharmacology and Molecular Docking to Investigate Boerhavia diffusa for Pancreatic Cancer Treatment
Abstract: Objective: In this study, network pharmacology was applied to determine the therapeutic effects of the bioactive compounds of Boerhavia diffusa. Network pharmacology can unearth the underlying mechanisms between drugs and the disease targets and aids in the discovery of novel medications for complex conditions such as cancer. Methods: To predict the molecular mechanisms of action of Boerhavia diffusa in the treatment of was screened using the GeneCards database. The Venn …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 1, 2024 · pp. 29–49 Read article
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A Comprehensive Review on Teaching Students with Learning Disabilities: The Potential of VR and AR Technology
Abstract: In terms of enhancing learning experiences, the use of virtual reality (VR) and augmented reality (AR) in education has shown encouraging outcomes. These technologies offer immersive, interactive environments that are extremely beneficial to students who struggle with learning. to assess how VR and AR affect learning outcomes in general as well as motivation, engagement, and academic performance. We'll examine how these resources might be applied to support children who face …
Published in International Journal of Children · Vol. 1, Issue 1, 2024 · pp. 31–36 Read article
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Whispers of the Microbial World: Unveiling Bacterial Dialogues through Quorum Sensing
Abstract: Quorum sensing is a special way of bacteria by which they can regulate their own gene expression as per the population density of the bacteria. It is basically a type of cell-to-cell communication pathway used by the microbes. The signal molecule which helps in this mechanism are called auto inducer(AI). As the mechanism depends by changes in the cell density, so when the cell density reaches to the threshold cell …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 14, Issue 3, 2024 · pp. 1–8 Read article