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88 articles for “background modeling”
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Existing Structures That Support Community Initiatives towards Addressing The Social Determinants of Health of Vulnerable Children
Abstract: Background: Community Initiatives are essential in support of vulnerable children to access healthcare, food, reasonable housing, education, income clean safe water and environment known as socialdeterminants of health. Weak structures for coordination, collaboration of social determinantsincreasing vulnerability amongst children in Suba sub county. This study explores existing structuressupporting community initiatives towards care of vulnerable children. Method: Descriptive crosssectional survey design was applied to investigate the problem qualitative and quantitative approachesused. …
Published in Journal of Nursing Science & Practice · Vol. 11, Issue 2, 2021 · pp. 60–71 Read article
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Workplace Violence against Women (WPVAW): The Experience among Healthcare Providers in Nigeria
Abstract: Background: Across the world today, the workplace just like any other public space a woman could find herself has become a place where the woman folk get abused by all categories of people they come in contact with, be it colleagues, service consumers, their relations amongst others.Aim: The study was aimed at assessing the prevalence of workplace violence against women, severity and perpetrators of abuse among healthcare providers in the …
Published in Research and Reviews: A Journal of Health Professions · Vol. 8, Issue 1, 2018 · pp. 42–46 Read article
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Predictors of Low Birth Weight in Tigrai Regional State, Northern Ethiopia: Hospital Based Case Control Study
Abstract: Background: Low birth weight is a serious public health crisis to neonatal survival, about 20.6 million such infants born each year and the developing world inhabits 96.5% of them and little is documented about the predictors of low birth weight in Ethiopia. Therefore, this study is intended to identify the determinants of low birth weight in governmental hospitals of Tigrai national state, Ethiopia.Method: A case-control study was carried out at …
Published in Research and Reviews: A Journal of Health Professions · Vol. 7, Issue 1, 2017 · pp. 23–32 Read article
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Relation of p53 Codon 72 Polymorphism with Breast Cancer Risk in DPR Korea Women
Abstract: Background: The p53 codon 72 polymorphism (rs1042522) is a single-nucleotide polymorphism (SNP) in exon 4 of p53 gene, resulting in the expression of either arginine (Arg), which encodes CGC, or proline (Pro), which encodes CCC. The p53 codon 72 polymorphism have been implicated as a risk factor for various cancers including breast cancer. We have investigated the association of the Arg/Pro polymorphism at codon 72 of p53 gene with breast …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 7, Issue 1, 2020 · pp. 23–30 Read article
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Pharmacophore mapping, 3D QSAR, docking, and ADME prediction studies of novel Benzothiazinone derivatives
Abstract: Background Tuberculosis is a major public health concern worldwide which is caused by Mycobacterium tuberculosis. DprE1 (Decaprenyl Phosphoryl Ribose 2’- Epimerase) is the most challenging target for development of novel anti- tubercular agents because it is a small protein and located into cytoplasmic membrane. So, novel anti-TB drugs did not bound effectively with it. DprE1 catalyzes the oxidation of the 2’ hydroxyl group of DPR (Decaprenyl Phosphoryl D- Ribose) …
Published in International Journal of Antibiotics · Vol. 1, Issue 1, 2024 · pp. 59–82 Read article
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Psychological Profile of Patients Undergoing Hemodialysis and Its Association with Physiological Parameters
Abstract: Background: End-stage renal disease (ESRD) is a chronic, progressive condition requiring maintenance hemodialysis, which imposes substantial physiological, psychological, and social burdens on patients. While physiological indicators are routinely monitored during treatment, the influence of psychological factors on these indicators and patients' quality of life remains inadequately explored, particularly in the Indian context. Objective: To investigate the relationship between psychological variables (depression, anxiety, illness intrusiveness, and quality of life) and physiological …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 16, Issue 2, 2026 · pp. 40–48 Read article
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Vitamin D Mitigates Inflammation and Downregulates Importin α3 in Non-Alcoholic Fatty Liver Disease (NAFLD)
Abstract: Background: Pro-inflammatory cytokines, such as TNF-α, IL-1β, IL-6, and IL-8, seem to play a crucial role in the progression of NAFLD as they activate the transcription factor NF-кB. The activated NF-кBp50/RelA subunits are translocated to the nucleus by Importin α3 and Importin α4. Numerous studies have indicated a negative association between NAFLD and vitamin D levels. Low vitamin D levels have been correlated with histological severity, necro-inflammation, and fibrosis in …
Published in International Journal of Cheminformatics · Vol. 4, Issue 1, 2026 · pp. 1–16 Read article
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Exploring Antimalarial Activity of Chalcone Derivatives through QSAR
Abstract: Background: The core structure of chalcones contains a reactive α,β-unsaturated system within the aromatic rings, which plays a key role in mediating various biological effects. These effects include enzyme inhibition, anticancer activity, anti-inflammatory properties, as well as antibacterial, antifungal, antimalarial, antiprotozoal, and anti-filarial actions.Modifying the structure by introducing substituent groups to the aromatic ring can enhance potency, reduce toxicity, and expand their range of pharmacological actions.Methods: A total of twenty-seven …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 2, 2025 · pp. 1–6 Read article