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105 articles for “Antigen”
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Characterization of a Broadly Specific LPS-Neutralizing Single Domain Antibody
Abstract: Gram negative endotoxaemia or sepsis remains a lethal challenge to humans and animals, globally. Single domain antibodies (dAbs) have emerged as therapeutic biologics for challenging antigens such as lipopolysachharide (LPS). The present study characterized a broadly specific LPS-neutralising dAb produced from phage display library from LPS-immunized Indian desert camel, for its sequence validation with mass spectrometry. Also, the dAb clone 26 was subjected to co-crystallisation with LPS, extracted from E. …
Published in Research and Reviews : A Journal of Immunology · Vol. 7, Issue 1, 2017 · pp. 1–7 Read article
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Mumps Outbreaks in Vaccinated Population
Abstract: The available approved safe and effective vaccines have prevented millions of deaths. When compared to prevaccine era, more than 98% decrease has been recorded for many diseases like diphtheria, invasive Haemophilus influenzae, measles, rubella, rotavirus, and hepatitis A. Further, the successful global eradication of small pox and near-elimination of polio from most of the global regions underlines the importance of vaccination. The available literature on mumps reveals that it is …
Published in Research and Reviews : A Journal of Immunology · Vol. 4, Issue 2, 2014 · pp. 8–11 Read article
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Vaccine Candidates and Animal Models for Kala-Azar
Abstract: Kala-azar or Visceral Leishmaniasis (VL) is a serious human disease in tropical regions and rapidly emerging as an opportunistic infection in HIV patients. The available treatment against VL is associated with toxicity and drug resistance. Even though the development of vaccines against VL is received limited attention. The only successful immunization strategy in humans has been leishmanization, which is based on the development of durable immunity after recovery from infection …
Published in Research and Reviews : A Journal of Immunology · Vol. 5, Issue 1, 2015 · pp. 29–35 Read article
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Immunologic Characteristics of Apparently Healthy Nigerians Exhibiting Abnormal SPE: A Preliminary Study
Abstract: Abnormal serum protein electrophoresis patterns have been discovered in apparently healthy Africans in Britain and Ghanaians living in Accra, Ghana. Conflicting reasons were suggested for this phenomenon. The aim of present study was to determine the prevalence and characteristics of serum protein electrophoresis (SPE) abnormalities in apparently healthy Nigerians living in Ogbomoso. Three hundred (300) apparently healthy subjects aged 20–30 years were selected for the study. SPE was performed on …
Published in Research and Reviews : A Journal of Immunology · Vol. 5, Issue 3, 2015 · pp. 1–6 Read article
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A Single-domain Antibody Cross-reacts with Lipopolysaccharide from Diverse Gram-negative Bacteria
Abstract: Gram-negative bacterial sepsis and endotoxemia are the leading causes of morbidity and mortality in animals and humans worldwide, and attempts have continued to design rational therapies. Endotoxin/lipopolysaccharide (LPS)-neutralizing polyclonal and monoclonal antibodies have been produced, but are not free from problems. Single-domain antibodies (dAbs), constructed from the camelid and the shark ‘heavy chain antibodies’ by phage display technology possess favorable features for in vivo applications. The objective of this study …
Published in Research and Reviews : A Journal of Immunology · Vol. 6, Issue 2, 2016 · pp. 29–37 Read article
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Cryptosporidium parvum Mediated Diarrhea in Immunocompromised Patients
Abstract: Cryptosporidium parvum is one of the important diarrheal agents, especially in malnourished children and immunocompromised patients. Of the many species, Cryptosporidium parvum and Cryptosporidium hominis are the two major species that cause water borne outbreaks. The geographic difference in the distribution of parasite has been attributed to sources and its mode of transmission. The parasite is able to survive in the environment for long time and is resistant to many …
Published in Research and Reviews : A Journal of Immunology · Vol. 6, Issue 3, 2016 · pp. 5–9 Read article
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In vivo Neutralization Efficacy of Chicken Egg Yolk Antibodies (IgY) Antibodies against Streptococcal Dental Caries
Abstract: Antibodies play an important role in preventing infectious disease and diminution of the chance of reinfections. Newly, the source of IgY is an effective method to develop antibodies to various diseases in humans or animals in future. IgY extracted from egg yolk collected from previously immunized white leghorn chickens and purification was done by precipitation and affinity chromatographic system. In-vivo studies were carried out in Wister rats which were divided …
Published in Research and Reviews : A Journal of Immunology · Vol. 10, Issue 1, 2020 · pp. 18–24 Read article
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Plantibodies as Edible Vaccine
Abstract: Plantibody is a plant derived antibody, which has been produced by genetically engineered plants. Antibodies which have proven itself as an important part of immune system in many organism’s act by recognizing viral antigens and other dangerous compounds and signal a response to it. In plant body formation, antibody coding genes from mammals will be inserted into plant’s genome, where they function same as natural mammalian antibodies. In plants, these …
Published in Research and Reviews : A Journal of Immunology · Vol. 10, Issue 1, 2020 · pp. 25–29 Read article
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Antiviral and Immunomodulatory Properties of Medicinal Mushrooms with Reference to Their Role in Treating COVID-19 Infections
Abstract: Emerging, respiratory coronavirus like severe acute respiratory syndrome coronavirus (SARS-CoV-2), producing the disease COVID-19 has become the major cause of posing biological threat to mankind in today’s world. It is referred as typical pneumonia associated inflammatory infection of lungs with high morbidity and mortality rate in humans. The virus has affected more than 200 countries across the world leading to death of more that 32,000,00 people across the globe, as …
Published in Research and Reviews : A Journal of Immunology · Vol. 11, Issue 2, 2021 · pp. 23–34 Read article
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A Research Study and Report on Impact of Clinical Pharmacy on Vaccine Safety, Vaccine Vigilance, ADR Assesment and Reporting Among Pediatrics During Active Immunization Schedules at ESI Hospital
Abstract: Vaccine is a biological preparation that improves immunity to a given vaccine-preventable disease (VPD). A vaccine typically contains a disease-causing microorganism, or portion of it, and is often made from either live-attenuated or inactivated (killed) forms of the microbe, its toxin or one of its surface proteins. Vaccines may be monovalent or polyvalent (multivalent).. The main Aim of the study is to explore the knowledge, attitudes and concerns with respect …
Published in Research and Reviews : A Journal of Immunology · Vol. 11, Issue 2, 2021 · pp. 35–45 Read article
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COVID-19: Impact on Human Health
Abstract: Researchers are on the cutting edge of devising the best strategy to combat the SARS-CoV-2 pandemic by studying and exploring the pathogenesis, prevention, and treatment as the world continues to be plagued by an increasing number of confirmed COVID-19 cases. The primary method for detecting the virus is via antigen testing and more accurate molecular tests such as rt PCR using patient samples. The most prevalent treatments for COVID-19 infection …
Published in Research and Reviews : A Journal of Immunology · Vol. 12, Issue 1, 2022 · pp. 1–8 Read article
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Accidentally Diagnosed Hepatic Hydatid Cyst: A Case Report
Abstract: Hydatid disease is a parasitic infection by a tape worm of Genus Echinococcus. It is a zoonotic disease that occurs throughout the world. The life cycle of E. granulosus alternates between herbivores and carnivores (Such as sheep & Dogs). Man is an accidental intermediate host and a dead end in parasites life cycle. The oral entry of parasite finds its host organ as intestinal mucosa where they develop into adult …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 10, Issue 2, 2021 · pp. 1–4 Read article
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Efficacy of Rapid Diagnostic Tests in Relation to ELISA in Hepatitis B and C Infection
Abstract: Background: Hepatitis B surface antigen and Hepatitis C antibodies in circulation are the common markers used for diagnosis of Hepatitis B and C infection. Though ELISA is the gold standard for detection of these markers, rapid diagnostic tests like immunochromatography is used in most of the centers for quick screening of cases. This study is undertaken to compare the result of both methods. Method: Both ICT and ELISA test were …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 10, Issue 2, 2020 · pp. 8–13 Read article
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A brief review on Influenza A virus (H 3 N 2 ) and its effects in human with precondition
Abstract: A primary cause of human influenza is the viral genus Influenzavirus A, of which H3N2 is a subtype. The virus has undergone various mutations, resulting in the emergence of different strains, affecting pigs, humans, and birds. H3N2 exchanges internal protein-coding genes with other influenza subtypes through reassortment. The H3N2 virus, which is a type of seasonal influenza A virus, is still circulating globally and is causing symptoms very similar to …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 13, Issue 1, 2023 · pp. 13–17 Read article
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Improvement of Motor and Sensory–Motor Behaviors after the Human Amniotic Epithelial Cells Transplantation in 6-OHDA Lesioned Corpus Striatum of Wistar Albino Rats
Abstract: Deficits in apomorphine-induced rotation and rotarod in rat have been proposed as a nondrug-induced model of the akinesia associated with the Parkinson’s disease. In the present study, we examined the disabilities in the rotarod and apomorphine-induced rotations have been observed after the 6-hydroxydopamine-induced denervation in the striatum. These impaired activities have reversed after the Human Amniotic Epithelial (HAE) cells transplantation during long-term observation. The neuronal densities and diameter were reduced …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 4, Issue 2, 2014 · pp. 34–45 Read article
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Correlation of Ki-67 Score with Nottingham Histological Grading in Carcinoma Breast: A Single Institution Experience
Abstract: Though it is reasonably well established that Ki-67 positivity is an independent predictor of ultimate prognosis and course of carcinoma breast and its recurrence, many lacunae exist. Ki -67 score correlation with histological grading will establish importance of nuclear antigen Ki-67 as prognostic factor in Indian population. This study was aimed to assess histological grading of breast carcinoma by Nottingham Grading System (Modified Scarff- Bloom- Richardson system) and to correlate …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 6, Issue 1, 2017 · pp. 1–5 Read article
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COVID-19 Prediction using X-Ray Images and Deep Learning Model
Abstract: In the year 2019, the novel corona virus was emerged in China. Since, then every individual has put their own self to fight against this pandemic situation. Till April 14, 2022, the total COVID-19 confirmed cases are 500,186,525 and deaths are 6,190,349 worldwide. RT-PCR and Rapid antigen test are the standards for COVID-19 detection by WHO. These both tests are time consuming and costly and also there are higher possibilities …
Published in Journal of Image Processing & Pattern Recognition Progress · Vol. 9, Issue 2, 2022 · pp. 24–32 Read article
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Assessment of the Saliva and Serum Interleukine-6 in Patients with Chronic Periodontitis: Case Controlled Study
Abstract: Abstract:Chronic periodontitis is a multifactorial disease characterized by an interaction between dental plaque antigen and components of the host defense system. Cytokines are considered to play a key role in the inflammation process in chronic periodontitis. The aim of the study was to assess the levels of Interleukin-6(IL-6) in saliva and serum of patients with chronic periodontitis and to compare them with the levels that observed in healthy subjects. This …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 5, Issue 1, 2015 · pp. 1–7 Read article
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Helicobacter pylori Sialic Acid-Specific Surface Lectin Associated with Pathogenecity Island cag PAI
Abstract: Normal 0 false false false MicrosoftInternetExplorer4 Helicobacter pylori bacterium causing gastritis, duodenitis, non-ulcer dyspepsia, adenocarcinoma, MALT lymphoma and now-a-days causing hepatocellular carcinoma and cholengiocarcinoma has been studied for its surface antigens. There are many virulence factors which have been studied since many years. Cag-PAI is the site for virulence and causes mixed infections. Sialic acid is a type of glycan which is a surface lectin associated with adherence to cell …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 5, Issue 3, 2015 · pp. 10–17 Read article
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Diagnosis of Dengue by NS1 Detection: Comparison of Rapid Immunochromatography versus ELISA Kits
Abstract: Dengue is an acute infectious disease of viral etiology. It is probably one of the most important arthropod borne viral disease in terms of human morbidity and mortality. The spectrum of disease ranges from self-limited dengue fever to more severe forms of dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS). So, to reduce mortality and morbidity early and accurate diagnosis of dengue is essential. Study assessed comparison of currently …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 6, Issue 2, 2016 · pp. 18–22 Read article