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178 articles for “receptors”
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Effect of Chronic Inescapable Footshock and Antidepressant Treatment on BDNF/TrkB Levels in Rat Hippocampus
Abstract: Depression is a major health problem globally. Chronic stress arising out of life style or social factors may trigger depression, the molecular basis of which has been attributed to alterations of brain chemicals like neurotrophins. Among these neurotrophins, brain-derived neurotrophic factor regulates many physiological functions in the brain, alteration of which has been well associated with the pathogenesis of depression. Stress-induced helplessness in rodents constitutes a well-defined model to investigate …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 2, Issue 2, 2012 · pp. 12–21 Read article
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Elementary Mechanisms and Therapeutic Approaches for Epilepsy: A Neurodegenerative Impairment
Abstract: The main reason of the epilepsy is both genetic as well as acquired sources. Conventionally developed origins comprise thoughtful brain trauma and difficulties consequential from aforementioned infection. Mostly, the reason of epilepsy is not clear. Seizures may also transpire as a moment of additional health complications, like stroke, head injury, toxic assimilation, or metabolic delinquent. Epilepsy is treacherous when seizure befalls throughout pregnancy. Convinced anti-epileptic medicines upsurge the jeopardy of …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 13, Issue 1, 2023 · pp. 41–46 Read article
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Brief Review on Novel Technology in Breast Cancer Chemotherapy
Abstract: Breast cancer is cancer that develops from breast tissue. Breast cells contain receptors for the two types of hormones estrogen and progesterone. They also contain receptors for a protein called HER2, which induce normal cell growth. Around two out of three women with breast cancer have cells that bear receptors for estrogen and progesterone, and just about 20–30% of breast cancers have too many HER2 receptors. Exploitation chemotherapy to treat …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 7, Issue 2, 2018 · pp. 22–26 Read article
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Docking Studies on Some Benzimidazole and Triazole Analogues as Antihypertensive Agents
Abstract: The incidence rate of hypertension continues a phenomenal rise and so, there is a growing need to identify novel therapeutic agents with improved efficacy and reduced side effects. In these circumstances, drugs acting on multiple targets could offer superior efficacy profiles compared with single target drugs. Some molecules have been designed using rational drug design approach and evaluated by performing docking studies. Targets used were an angiotensin-converting enzyme, angiotensin receptor, …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 5, Issue 2, 2018 · pp. 37–39 Read article
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A review: Emphasis on the connection between hormones modifiable plasma lipids and metabolism of lipid in obesity
Abstract: Lipid dysfunction directly related with the obesity because increased low-density lipoprotein and triglyceride level elevated causes obesity by various mechanism. Many complications produce due to disturb metabolism of fatty acid and transferring in between various tissues. Current effort sophisticatedly established impaired fatty acid insnaring in obese persons. Additionally, overweight individuals have declined acceptance of nutritional fat through adipose tissue primary level due to this reason low-density lipoprotein level increase in …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 13, Issue 1, 2023 · pp. 1–5 Read article
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Pharmacokinetic Profiling and Molecular Docking of Carvacrol and Structural Analogs: Targeting Quorum Sensing Proteins to Disrupt Biofilm-Mediated Antimicrobial Resistance in Multidrug-Resistant Bacterial Pathogen
Abstract: Antibiotic resistance, particularly in Pseudomonas aeruginosa, has become a major global health threat, exacerbated by the organism's ability to form biofilms and regulate virulence through quorum sensing (QS). The LuxR and LasR receptors are key regulators in this process, influencing both pathogenicity and antibiotic resistance. This study investigates potential QS inhibitors targeting these receptors as a strategy to mitigate antibiotic resistance. The primary objective was to identify novel ligands that …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 3, Issue 2, 2025 · pp. 43–61 Read article
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Study of Polycystic Ovary Syndrome (PCOS) with Special Reference to Candidate Genes
Abstract: The PCOS (polycystic ovary syndrome) has become a worldwide concern as progression of PCOS in the age group of adolescence to postmenopausal women is increasing. In India, sudden rapid growth in PCOS is observed in the range of 3.7–22.5%. Effects of PCOS are not only on the reproductive and metabolic systems, but the whole body’s metabolism gets affected; ultimately, it leads to different life- style diseases like type 2 diabetes …
Published in Research and Reviews: A Journal of Health Professions · Vol. 13, Issue 1, 2023 · pp. 49–55 Read article
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Frequency and Effect of CCR5 Alleles on HIV-1 Disease Progression among Untreated Seropositive Individuals Visiting Gondar University Teaching Hospital
Abstract: Abstract:The natural history of HIV-1 infection varies considerably from one individual to another, with some individuals progressing to AIDS rapidly after primary infection, while others remain clinically asymptomatic with no evidence of immune dysfunction. Recent studies have shown that reasons for progression and non-progression are multi-factorial and may involve genetic, virological and immunological factors that influence HIV disease progression in various ways. Chemokine receptors act as important co-receptors mediating the …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 5, Issue 1, 2015 · pp. 8–13 Read article
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Pharmacophore Mapping of Dengue Virus Inhibitors of Natural Origin Using Phase and Self Organizing Neural Networks
Abstract: Dengue virus (DENV) infection is an important arthropod-born viral infection infecting about 2.5 billion people worldwide. To date there are no effective vaccine or antiviral treatment for dengue. Dengue patients are usually supportively treated until they recover without any specific treatment measures. Plants and plant’s derived compounds remain an important source for the discovery and the development of new antiviral drugs because of their expected low side effects and their …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 1, Issue 2, 2014 · pp. 1–18 Read article
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Perspectives on ‘Kamsaharitaki’: an Ayurvedic Formulation for COVID-19 related Multisystem Inflammatory Syndrome (MIS)
Abstract: Background and Aim: Angiotensin-converting enzyme 2 receptor (ACE2), together with Transmembrane protease serine 2 (TMPRSS2), is a protein receptor for SARS-CoV-2 virus in the host subject; expression of ACE2 and TMPRSS2 reveals the multidimensional character of COVID-19 infection. SARS-CoV-2 Prominently induces pulmonary and systemic injury with other synergistic mechanisms. Preexisting chronic inflammatory conditions markedly sustain and aggravate the severity and cytokine storm. Inflammatory responses are closely linked with COVID-19 severity …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 11, Issue 1, 2022 · pp. 28–39 Read article
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Synthesis of Brassinosteroid with Signaling and Response to Abiotic Stress: Review
Abstract: Brassinosteroids (BRs) are a group of plant steroid hormones with multiple roles in plant growth, development, and responses to stresses and signaling functions to promote cell expansion and cell division and plays a role in etiolation and reproduction. The entire synthetic pathway of sterol biosynthesis is brassinolide (BL) from the general campesterol synthesis pathway in Arabidopsis. Campesterol converts to BL in two different ways campesterol dependent or campesterol independent pathway. …
Published in Research & Reviews : Journal of Botany · Vol. 10, Issue 4, 2021 · pp. 24–32 Read article
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In Silico Drug Design for Mycobacterium tuberculosis and Development of Host–Pathogen Interaction Network and Molecular Docking Procedures
Abstract: Objective: A leading cause of illness is the contagious disease tuberculosis (TB), this infection with Mycobacterium tuberculosis complex (MTBC) particularly M. tuberculosis and M. africanum, is what causes tuberculosis. Diverse receptor proteins (mycobacterial proteins) with various 3D structures and functions were evaluated to access the multi-domain antimycobacterial action of ligands. The specific receptor proteins PDB ID: 3PTY, PDB ID: 4OW8, PDB ID: 5KWA, and PDB ID: 3ZXR, were opted for …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 1, 2023 · pp. 1–19 Read article
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Extrapolations of Periwinkle Secondary Metabolites as Multitarget Inhibitor of Breast Cancer Proteins
Abstract: Objective: Breast cancer is considered one of the most common and dangerous forms of cancer. It is a significant public health issue on a global scale. The study estimates that 10.0 million people will die from cancer this year, and 19.3 million people will develop the disease overall (BC). In this computation approach, nowadays emphasizes new drug discovery, the target protein epidermal growth factor receptor (EGFR) (5UGB), estrogen receptor (ER) …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 1, Issue 1, 2023 · pp. 36–49 Read article
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Deciphering the Pathophysiology of Migraine: Understanding Trigeminovascular System Activity and the Importance of the Gut-Brain Axis
Abstract: Migraine, a prevalent and disabling neurological condition, manifests in distinct phases: premonitory, aura, headache, postdrome, and interictal. Being a primary contributor to adult disability, it presents a substantial economic challenge on a global scale. Even with extensive research spanning centuries, the complete grasp of its root causes continues to evade us. This intricate neurovascular disorder primarily involves local vasodilation of intracranial and extracerebral blood vessels, coupled with simultaneous stimulation of …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 1, 2024 · pp. 50–61 Read article
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Rethinking Type-1 Diabetes Treatment: Emerging Medicines Based on AAT Therapy and C-peptide Preservation Therapy
Abstract: The increasing number of cases, especially in the younger age group, along with the lack of accessible clinical solutions, make Type-1 Diabetes (T1D) a growing global health concern. While gene therapy and transplantation approaches are promising avenues, their excessively high costs and logistical difficulties make them inaccessible to the majority and can impose a financial burden on those suffering from it, adding to the challenges already faced by these advanced …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 14, Issue 3, 2024 · pp. 19–29 Read article
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Stingless Honeybee’s Rare Sugar and PCSK 9 - LDLR Interaction, A New Hope for Hormone Dependent Breast Cancer Patients – An In-silico Study
Abstract: Hypercholesterolemia is a lipid disorder characterized by elevated levels of low-density lipoprotein (LDL), commonly known as "bad" cholesterol. This condition is a significant risk factor in the development and progression of hormone-dependent breast cancer, as well as in the emergence of resistance to hormonal therapy. One of the key regulators of cholesterol metabolism is the proprotein convertase subtilisin/kexin type-9 (PCSK9) protein, which facilitates the degradation of the LDL receptor (LDLR) …
Published in International Journal of Cheminformatics · Vol. 3, Issue 1, 2025 · pp. 1–6 Read article
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Assessing the Clinical Efficacy and Safety of Semaglutide: A Comprehensive Study
Abstract: Semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA), has emerged as a versatile therapeutic agent with significant potential in managing a range of diseases. Extensive research has demonstrated its efficacy in treating obesity, type 1 and type 2 diabetes, and even neurodegenerative disorders like Parkinson’s disease. This comprehensive review examines the principal outcomes derived from clinical trials that incorporate semaglutide alongside other GLP-1 agonists, with particular emphasis on the mechanisms underlying …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 96–104 Read article
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Tobacco and COVID-19: Molecular Interactions and Public Health Challenges – A Review
Abstract: Tobacco use exacerbates health risks, making it a significant concern during the COVID-19 pandemic. Smoking has been implicated in the upregulation of ACE2 receptors, critical for SARS- CoV-2 entry, and contributes to immune dysregulation and oxidative stress, worsening clinical outcomes. Methods: This review synthesizes evidence on the molecular mechanisms linking tobacco and COVID-19, assesses risk factors, such as smoking status and comorbidities, and explores public health challenges in managing the …
Published in International Journal of Virus Studies · Vol. 2, Issue 1, 2025 · pp. 1–6 Read article
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Exploring Oroxylum indicum Phytochemicals as VEGFR-2 Inhibitors: A Molecular Docking Approach for Cancer Management
Abstract: Cancer is still a major health problem around the world and is one of the top causes of death. A protein called VEGFR-2 (vascular endothelial growth factor receptor 2) is important because it helps blood vessels grow by supporting the survival, movement, and growth of certain cells. This process is essential for tumors to grow and spread to other parts of the body. This study focused on evaluating the binding …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 · pp. 48–62 Read article
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Gold Nanoparticle Size, Biodistribution, and Toxicity: Insights from DualEnergy CT
Abstract: Dual-energy and spectral computed tomography (CT) have emerged as powerful platforms for noninvasive, quantitative mapping of nanoparticle biodistribution in vivo. By exploiting the energy-dependent attenuation profiles of high-atomic-number (high-Z) materials, these systems enable material decomposition and element-specific imaging, thereby distinguishing nanoparticle signals from those of soft tissues and conventional iodinated contrast agents. Photon-counting spectral CT further enhances this capability by binning individual photons into multiple energy channels, improving spatial resolution, …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 28, Issue 2, 2025 · pp. 22–34 Read article