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423 articles for “Gene targeting”
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Pharmacophore mapping, 3D QSAR, docking, and ADME prediction studies of novel Benzothiazinone derivatives
Abstract: Background Tuberculosis is a major public health concern worldwide which is caused by Mycobacterium tuberculosis. DprE1 (Decaprenyl Phosphoryl Ribose 2’- Epimerase) is the most challenging target for development of novel anti- tubercular agents because it is a small protein and located into cytoplasmic membrane. So, novel anti-TB drugs did not bound effectively with it. DprE1 catalyzes the oxidation of the 2’ hydroxyl group of DPR (Decaprenyl Phosphoryl D- Ribose) …
Published in International Journal of Antibiotics · Vol. 1, Issue 1, 2024 · pp. 59–82 Read article
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Thermo-hydraulic Performance of Multi-Pass Double-Pipe Heat Exchangers: Integrating Polymer Composite Tube Wall Materials via CFD Parametric Study and Experimental Validation
Abstract: Metallic materials such as steel and copper have traditionally dominated heat exchanger manufacturing because of their excellent thermal conductivity, mechanical strength, and long-established industrial reliability. However, their high weight, susceptibility to corrosion in aggressive operating environments, and inability to provide tunable thermal properties have motivated interest in alternative materials for next-generation thermal systems. Thermally conductive polymer composites reinforced with graphene nanoplatelets (GNP), boron nitride (BN), and carbon-based fillers offer an …
Published in Journal of Polymer & Composites · Vol. 14, Issue 5, 2026 Read article
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THE BURDEN OF EMPIRICAL THERAPY: ANALYZING THE PREDOMINANCE OF BROAD-SPECTRUM ANTIBIOTIC USAGE IN LOWER RESPIRATORY TRACT INFECTIONS
Abstract: Lower respiratory tract infections (LRTIs) remain one of the leading causes of morbidity and hospitalization worldwide, particularly among older adults, immunocompromised individuals, and patients with chronic respiratory disorders. These infections include conditions such as community-acquired pneumonia, hospital-acquired pneumonia, bronchitis, and acute infective exacerbations of chronic lung disease, all of which often require rapid clinical intervention. Because microbiological confirmation of the causative pathogen frequently takes 48–72 hours, clinicians generally initiate empirical …
Published in International Journal of Antibiotics · Vol. 3, Issue 2, 2026 Read article