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Research & Reviews: A Journal of Pharmacognosy

Combined Potential of Formulated diet (Pearl millet, Hungary rice, Moringa oleifera leaves and Cray fish) with Glibenclamide on Fasting blood glucose and lipid profile in alloxan induced diabetic wistar rats

  1. Musa Bashir

Abstract

Background:The Interest to practice drug-food/nutrient interaction will not be overemphasis, however,the recognition of its importance to practice has been growing much slower. The aim of the study:Thisstudy aimed to identify combined effect of a formulated diet with glibenclamide on fasting bloodglucose and serum lipid profile in alloxan induced diabetic wister rats. Materials and methods: For thisinvestigation, 55 male albino wistar rats were randomly assigned to eleven groups of five. They receiveddosage/Treatment for a period of 28 days. Fasting blood glucose of all rats was taken weekly for fourweeks. Lipid profile assays was done using Cardio-Chek professional analyzer. Results: Glycemicindex and glycemic load of the formulated diet were found to be 67.60% and 51.15% respectively.There was a significant (p<0.05) glibenclamide and designed diet treatment groups experienced adecrease in fasting blood sugar compared to the diabetes control groups at p<0.05. Also, a significantreduction was observed in the serum lipid profile parameters (p<0.05) in groups given combinedtreatment of formulated diet and glibenclamide as compared to groups given single treatments offormulated diet or Glibenclamide alone. Conclusions: It can be concluded that combination of aFormulated diet (Pearl millet, Hungary rice, Moringa oleifera leaves and Cray fish) and glibenclamidemay be useful in diabetes mellitus management.
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