Chemical Constituents and Antacid Activity of Aqueous Extract of the Leaves of Sanchezia nobilis Hook.f. from Vietnam

Loi Vu Duc; Xuan Bui Thi; Ngoc Tran Minh

Abstract

From the aqueous extract of the leaves of Sanchezia nobilis Hook.f. collected in Nam Dinh province by chromatographic methods. Their chemical structures were elucidated by the measurements of melting temperature, rotation angle, mass spectrometry (MS), nuclear magnetic resonance (NMR) and compared with previously published data. These were identified as: 4',5,7-trihydroxy-3',5'-dimethoxyflavone (NX1), kaempferol-3-O-α-L-arabinofuranoside (NX2), kaempferol-3-O-β-D-glucopyranoside (NX3). These all compounds were isolated from the leaves of Sanchezia nobilis for the first time. Evaluation the antacid activity of the n-hexane, ethylacetate and water fractions from the extract of this plant showed that the antacid effect of water fraction was better than the other two fractions, but the underlying trend remained weaker than that of antacid Antigas. Keywords: Sanchezia nobilis Hook.f, 4',5,7-trihydroxy-3',5'-dimethoxyflavone, kaempferol-3-O-α-L-arabinofuranoside, kaempferol-3-O-β-D-glucopyranoside.Cite this ArticleLoi Vu Duc, Xuan Bui Thi, Ngoc Tran Minh. Chemical Constituents and Antacid Activity of Aqueous Extract of the Leaves of Sanchezia nobilis Hook.f. from Vietnam. Research & Reviews: A Journal of Pharmacognosy. 2019; 6(2): 15–22p.