Analysis of Serum PSA Level and Various Prostatic Pathologies in South-East Rajasthan

Mukesh Vijayvergia; Gulab Kanwar; Imran Hussain; Remesh Kunjunni

doi:10.37591/rrjooh.v11i3.3086

Abstract

Background: Prostate-specific antigen (PSA), an organ-specific tumor marker secreted by the prostate gland exclusively is frequently asked for investigation among men in the second half of life. Although it is a useful marker in carcinoma prostate, simultaneously it is clinically imprecise as benign and malignant lesions, both can have elevated serum levels of PSA. The objective of this research study was to identify whether or not there is a connection in between the degree of prostate-specific antigen in the product and also the histological medical diagnosis of prostatic ailments. Materials and Materials: This research occurred throughout 1 year at the division of Biochemistry at the Government Medical College in Kota and also the accompanying Health centers. In total, 95 situations including prostatic lesions were considered for this investigation. The chemiluminescent immunoassay (CLIA) technique was made use of in order to examine the PSA degrees of these certain patients. The division of pathology at the Government Medical College in Kota did a histopathological analysis of the tissue examples gotten following transurethral resection and core biopsy of the prostate. The H/P of tissues, in addition to their connection to the levels of prostate-specific antigen, were examined. Results: Malignant lesions in the prostate are seen at a higher level of serum PSA; (above 20 ng/ml). Benign prostatic hyperplasia was the most common pathology encountered (n=56; 59%), and serum PSA levels among most of them are below the level of 20 ng/ml. 34 out of 56 patients with BPH are associated with inflammatory pathology along benign hyperplastic pathologies. Both malignant and benign pathologies are seen in men in the 6th and 7th decade of life. Conclusions: Prostatic-specific antigen is an antigen that is just located in prostatic tissue and rises in benign as well as malignant sores of the prostate. But the chances of malignancy are found to increase with the rising values of PSA. Higher levels of serum PSA (>20 ng/ml) are almost associated with prostatic carcinoma. Association of chronic prostatitis with benign prostatic hyperplasia is quite common. Serum PSA level in patients with benign prostatic hyperplasia is below 20 ng/ml (mainly found at a range of 0–10 ng/ml). Elevated serum PSA level in men seeks attention and demands a detailed evaluation. The study had the greatest incidence of benign prostatic hyperplasia, which is one of the most widespread pathological findings.