First trimester neutrophil-lymphocyte ratio in pregnancy associated with preeclampsia patients in India: A brief review.

Sumer Singh; Tarang Gupta

doi:10.37591/rrjols.v13i3.3781

Abstract

Background: Pre-eclampsia is a complicated syndrome that starts very early in pregnancy and has a known pathogenesis. However, the second or third trimester is when its clinical symptoms first manifest. Preeclampsia and NLR are related, according to the literature review, albeit the findings are ambiguous and contradicting. Moreover, there isn't a thorough assessment available from Indian contexts. As a result, the current review was designed with the goal of examining the NLR in preeclampsia, examining its significance for early identification, severity assessment, prognosis, and determining the NLR cutoff value. Method: Initially, 57 studies in total were obtained from databases. Following the elimination of duplicates, 28 studies in total were reviewed. Ten of those studies were eventually included in the qualitative and quantitative analysis after they satisfied the inclusion criteria. the specifics of the chosen papers from Indian healthcare settings between 2017 and 2023. Findings: A comprehensive analysis of 10 relevant studies comparing NLR in 678 preeclamptic participants with 1743 normotensive expectant mothers revealed a statistically significant overall effect supporting the utility of NLR investigations in preeclamptic prediction. According to the current review, NLR is a highly valuable predictor of preeclampsia. Preeclampsia is thought to be caused by placental hypoxia, which may be connected to this rise during 18 weeks of gestation. To the best of our knowledge, several more studies—the first of its sort conducted in Indian settings—are included in the current review. It is clear that NLR is a practical, affordable, and quick biomarker for preeclampsia. In conclusion, the review indicates that NLR is a valuable hematological marker that can be used for preeclampsia assessment and prediction. But it's also important to keep in mind that there are other important factors that can affect NLR in preeclampsia.