Research and Reviews: A Journal of Health Professions Review Article

Retained Placenta in Dairy Cows: Causes, Consequences and Effective Strategies for Sustainable Dairy Development

  1. Md. Emran Hossain Department of Animal Science and Nutrition, Chattogram Veterinary and Animal Sciences University, Khulshi

Abstract

Retained placenta (RP) is a common reproductive disorder in dairy cows that poses a significant threat to reproductive efficiency, milk yield, and overall herd productivity. The condition, characterized by the failure to expel fetal membranes within 24 hours post-calving, results from a complex interplay of metabolic, endocrine, nutritional, and management-related factors. Key causative agents include dystocia, twin births, premature calving, mineral imbalances, oxidative stress, immune suppression, and hormonal disruptions, particularly involving prostaglandins and oxytocin. The consequences of RP are multifaceted, ranging from metritis, endometritis, and reduced conception rates to extended calving intervals, increased culling, and elevated veterinary expenses. Moreover, the condition compromises animal welfare and increases the environmental footprint of dairy operations due to inefficient resource utilization. Addressing RP is critical for promoting sustainable dairy development, particularly under tropical and subtropical conditions where stressors are more pronounced. Effective strategies include early diagnosis, improvement of transition cow nutrition, targeted mineral supplementation, stress mitigation, enhancement of periparturient immunity, and refinement of calving management practices. Emphasis must also be placed on adopting precision dairy technologies and herd health monitoring systems to enable timely interventions. This review underscores the need for integrative approaches that align reproductive health with sustainability goals, thereby fostering resilient and productive dairy systems.

Keywords

References (66)

  1. Jain T, Yadav DK, Shubham, Manisha. Retained placenta in bovines: Current understanding and future directions. International Journal of Research in Agronomy. 2024;7(9S):84-87. doi:10.33545/2618060x.2024.v7.i9sb.1428
  2. Kashoma I, Ngou AA. Retained fetal membrane in Tanzanian dairy cows: Economic impacts and subsequent reproductive performances. 2025. Available from: https://www.researchgate.net/profile/Athanas-Ngou/publication/388617005_Subsequent_Reproductive_Performances/links/679f3e6196e7fb48b9aeab18/Subsequent-Reproductive-Performances.pdf
  3. Rasmussen P, Barkema HW, Osei PP, Taylor J, Shaw AP, Conrady B, et al. Global losses due to dairy cattle diseases: A comorbidity-adjusted economic analysis. Journal of Dairy Science. 2024;107(9):6945-6970. doi:10.3168/jds.2023-24626
  4. Coman S, Berean DI, Cimpean R, Ciupe S, Coman I, Bogdan LM. Comparative Evaluation of Classic Treatment and Novel Intrauterine Infusion for Retained Placenta in Buffaloes: Impacts on Reproductive Performance and Economic Losses. Animals. 2025;15(5):711. doi:10.3390/ani15050711
  5. Huralska S, Yevtukh L, Hryshchuk H, Honcharenko V, et al. Technology of manufacture and efficacy of obstetric pessaries for preventive therapy in cows. Scientific Horizons. 2025;28(4):9–19. Available from: https://sciencehorizon.com.ua/web/uploads/pdf/Scientific%20Horizons_2025_Vol.%2028,%20No.%204-9-19.pdf
  6. Amin YA, Hussein HA. Latest update on predictive indicators, risk factors and ‘Omic’ technologies research of retained placenta in dairy cattle – A review. Reproduction in Domestic Animals. 2022;57(7):687-700. doi:10.1111/rda.14115
  7. Kamel ER, Ahmed HA, Hassan FM. The effect of retained placenta on the reproductive performance and its economic losses in a Holstein dairy herd. Iraqi Journal of Veterinary Sciences. 2022;36(2):359-365. doi:10.33899/ijvs.2021.130287.1791
  8. Küçükoflaz M, Sariözkan S. Financial losses related to placental retention in dairy herds in Turkey. Arquivo Brasileiro de Medicina Veterinária e Zootecnia. 2022;74(6):955-960. doi:10.1590/1678-4162-12782
  9. Mahnani A, Sadeghi-Sefidmazgi A, Ansari-Mahyari S, Ghorbani GR, Keshavarzi H. Farm and cow factors and their interactions on the incidence of retained placenta in holstein dairy cows. Theriogenology. 2021;159:87-97. doi:10.1016/j.theriogenology.2020.10.007
  10. A. Amin Y, Mohammed Zakaria A, Hasan AS. The Efficacy of Treatment of Retained Placenta with Chlortetracycline and Oxytetracycline through Local Intrauterine Route in Dairy Cows. Journal of Animal Health and Production. 2020;9(2). doi:10.17582/journal.jahp/2021/9.2.100.106
  11. BAQIR Y, SAKHAWAT A, TABBASUM R, AWAIS T, BALOCH S, SUBHANI A, et al. Therapeutic management of milk fever with retained placenta in Holstein Friesians cow in a private dairy farm at Sheikhupura, Punjab-Pakistan. Multidisciplinary Science Journal. 2021;3(1):e2021015. doi:10.29327/multiscience.2021015
  12. Magata F, Sone A, Watanabe Y, Deguchi Y, Aoki T, Haneda S, et al. Prevention of retained fetal membranes and improvement in subsequent fertility with oxytocin administration in cows with assisted calving. Theriogenology. 2021;176:200-205. doi:10.1016/j.theriogenology.2021.09.037
  13. Abdisa T. Review on the Reproductive Health Problem of Dairy Cattle. Journal of Dairy & Veterinary Sciences. 2018;5(1). doi:10.19080/jdvs.2018.05.555655
  14. Komba EV, Kashoma IP. Prevalence and economic impacts of retained placenta and subclinical mastitis in Tanzanian dairy cows. 2020. Available from: https://www.researchsquare.com/article/rs-10984/latest
  15. Kebede A, Mohammed A, Tadessse W, Abera D. Review on economic impacts of dystocia in dairy farm and its management and prevention methods. Nat Sci. 2017. Available from: http://www.sciencepub.net/natureonline
  16. Abdela N, Ahmed WM. Risk factors and economic impact of dystocia in dairy cows: A systematic review. 2016. Available from: https://www.researchgate.net/profile/Nejash-A Ahmed/publication/303823978_Risk_Factors_and_Economic_Impact_of_Dystocia_in_Dairy_Cows_A_Systematic_Review/links/
  17. Tucho TT. Review on retention of placenta in dairy cows and its economic and reproductive impacts. J Nat Sci Res. 2017;7(7):28–37. Available from: www.iiste.org
  18. López-Gatius F. Twins in Dairy Herds. Is It Better to Maintain or Reduce a Pregnancy? Animals. 2020;10(11):2006. doi:10.3390/ani10112006
  19. Islam M, Sarder M, Rahman M, Kader M, Islam M. Incidence of Retained Placenta in Relation with Breed, Age, Parity and Body Condition Score of Dairy cows. International Journal of Natural Sciences. 2012;2(1):15-20. doi:10.3329/ijns.v2i1.10878
  20. Yazlık MO, Çolakoğlu HE, Pekcan M, Kaya U, Kaçar C, Vural MR, et al. The evaluation of superoxide dismutase activity, neutrophil function, and metabolic profile in cows with retained placenta. Theriogenology. 2019;128:40-46. doi:10.1016/j.theriogenology.2019.01.020
  21. Seifi HA, Kia S. Subclinical hypocalcemia in dairy cows: Pathophysiology, consequences and monitoring. Iran J Vet Sci Technol. 2018;9(2):1–15. Available from: https://ijvst2.um.ac.ir/index.php/veterinary/article/view/69198
  22. Eger S, Drori D, Kadoori I, Miller N, Schindler H. Effects of Selenium and Vitamin E on Incidence of Retained Placenta. Journal of Dairy Science. 1985;68(8):2119-2122. doi:10.3168/jds.s0022-0302(85)81077-8
  23. Allison RD, Laven RA. Effect of vitamin E supplementation on the health and fertility of dairy cows: A review. Vet Rec. 2000;147(25):703–708. doi:10.1136/vr.147.25.703.
  24. Bzuneh E, Alemneh T, Getabalew M. Milk fever (parturient paresis) and its economic impact in dairy cattle production. 2020. Available from: https://www.researchgate.net/publication/343345516
  25. Mordak R, Stewart PA. Periparturient stress and immune suppression as a potential cause of retained placenta in highly productive dairy cows: examples of prevention. Acta Veterinaria Scandinavica. 2015;57(1). doi:10.1186/s13028-015-0175-2
  26. Sheldon IM, Molinari PCC, Ormsby TJR, Bromfield JJ. Preventing postpartum uterine disease in dairy cattle depends on avoiding, tolerating and resisting pathogenic bacteria. Theriogenology. 2020;150:158-165. doi:10.1016/j.theriogenology.2020.01.017
  27. Wiltbank MC, Baez GM, Garcia-Guerra A, Toledo MZ, Monteiro PLJ, Melo LF, et al. Pivotal periods for pregnancy loss during the first trimester of gestation in lactating dairy cows. Theriogenology. 2016;86(1):239-253. doi:10.1016/j.theriogenology.2016.04.037
  28. Simões J, Stilwell G. Puerperal Complications in the Dam. Calving Management and Newborn Calf Care. 2021:209-237. doi:10.1007/978-3-030-68168-5_9
  29. Hassan M, Nasreldin N, El-Zeftawy M. Serum Biochemical Investigations on Retained Placenta in Egyptian Buffaloes. Advances in Animal and Veterinary Sciences. 2019;8(1). doi:10.17582/journal.aavs/2020/8.1.67.76
  30. Velladurai C, Selvaraju M, Napolean RE. Effects of macro and micro minerals on reproduction in dairy cattle: A review. 2016. Available from: https://www.academia.edu/download/80500967/230.pdf
  31. Mordak R, Nicpoń J, Illek J. Metabolic and mineral conditions of retained placenta in highly productive dairy cows: pathogenesis, diagnostics and prevention – a review. Acta Veterinaria Brno. 2017;86(3):239-248. doi:10.2754/avb201786030239
  32. Wilde D. Influence of macro and micro minerals in the peri-parturient period on fertility in dairy cattle. Animal Reproduction Science. 2006;96(3-4):240-249. doi:10.1016/j.anireprosci.2006.08.004
  33. Xiao J, Khan MZ, Ma Y, Alugongo GM, Ma J, Chen T, et al. The Antioxidant Properties of Selenium and Vitamin E; Their Role in Periparturient Dairy Cattle Health Regulation. Antioxidants. 2021;10(10):1555. doi:10.3390/antiox10101555
  34. Jovanović IB, Veličković M, Vuković D, Milanović S, Valčić O, Gvozdić D. Effects of Different Amounts of Supplemental Selenium and Vitamin E on the Incidence of Retained Placenta, Selenium, Malondialdehyde, and Thyronines Status in Cows Treated with Prostaglandin F2α for the Induction of Parturition. Journal of Veterinary Medicine. 2013;2013:1-6. doi:10.1155/2013/867453
  35. Yasothai R. Importance of protein on reproduction in dairy cattle. 2014. Available from: www.ijset.net
  36. IBTISHAM F, NAWAB A, LI G, XIAO M, AN L, NASEER G. Effect of nutrition on reproductive efficiency of dairy animals. Medycyna Weterynaryjna. 2018;74(1):6025-2018. doi:10.21521/mw.6025
  37. University College Dublin, Ireland, Evans ACO, Zeng S, China Agriculture University, China. Causes, prevention and management of infertility in dairy cows. Burleigh Dodds Series in Agricultural Science. 2017:385-398. doi:10.19103/as.2016.0006.20
  38. Mahnani A, Sadeghi-Sefidmazgi A, Ansari-Mahyari S, Ghorbani GR. Assessing the consequences and economic impact of retained placenta in Holstein dairy cattle. Theriogenology. 2021;175:61-68. doi:10.1016/j.theriogenology.2021.08.036
  39. Cui D, Wang L, Wang L, He J, Li Y, Zhang Z, et al. Efficacy of an herbal formula Guixiong Yimu San in preventing retained placenta and improving reproductive performance in cows. Scientific Reports. 2024;14(1). doi:10.1038/s41598-024-63521-x
  40. Esposito G, Irons PC, Webb EC, Chapwanya A. Interactions between negative energy balance, metabolic diseases, uterine health and immune response in transition dairy cows. Animal Reproduction Science. 2014;144(3-4):60-71. doi:10.1016/j.anireprosci.2013.11.007
  41. Esposito G, Irons PC, Webb EC, Chapwanya A. Interactions between negative energy balance, metabolic diseases, uterine health and immune response in transition dairy cows. Animal Reproduction Science. 2014;144(3-4):60-71. doi:10.1016/j.anireprosci.2013.11.007
  42. Yusuf JJ. A Review on Retention of Placenta in Dairy Cattles. Int J Vet Sci. 2016. Available from: www.ijvets.com
  43. Li Y, Zhao Z, Yu Y, Liang X, Wang S, Wang L, et al. Plasma Metabolomics Reveals Pathogenesis of Retained Placenta in Dairy Cows. Frontiers in Veterinary Science. 2021;8. doi:10.3389/fvets.2021.697789
  44. Rao TKS. Fetal Membranes and Associated Complications in Dairy Animals: A Review. Theriogenology Insight- An International Journal of Reproduction in All Animal. 2018;8(3). doi:10.30954/2277-3371.03.2018.6
  45. Li Y, Wen H, Yang Y, Zhao Z, Gao H, Li H, et al. Potential prognostic markers of retained placenta in dairy cows identified by plasma metabolomics coupled with clinical laboratory indicators. Veterinary Quarterly. 2022;42(1):199-212. doi:10.1080/01652176.2022.2145619
  46. Smith BI, Risco CA. Management of Periparturient Disorders in Dairy Cattle. Veterinary Clinics of North America: Food Animal Practice. 2005;21(2):503-521. doi:10.1016/j.cvfa.2005.02.007
  47. Fricke PM, Shaver RD. Managing reproductive disorders in dairy cows. 2001. Available from: https://www.researchgate.net/profile/Paul-Fricke/publication/251762927
  48. Bačić G, Karadjole T, Mačešić N, Karadjole M. A brief review of etiology and nutritional prevention of metabolic disorders in dairy cattle. 2007. Available from: http://image.sciencenet.cn
  49. Bonneville-Hébert A, Bouchard É, Du Tremblay D, Lefebvre R. Effect of reproductive disorders and parity on repeat breeder status and culling of dairy cows in Quebec. Can J Vet Res. 2011;75(2):147–151. Available from: https://www.ingentaconnect.com
  50. Oresnik A. Effect of health and reproductive disorders on milk yield and fertility in dairy cows. The Bovine Practitioner. 1995:43-45. doi:10.21423/bovine-vol1995no29p43-45
  51. Qu Y, Fadden AN, Traber MG, Bobe G. Potential risk indicators of retained placenta and other diseases in multiparous cows. Journal of Dairy Science. 2014;97(7):4151-4165. doi:10.3168/jds.2013-7154
  52. Rodríguez EM, Arís A, Bach A. Associations between subclinical hypocalcemia and postparturient diseases in dairy cows. Journal of Dairy Science. 2017;100(9):7427-7434. doi:10.3168/jds.2016-12210
  53. Galvão KN. Postpartum uterine diseases in dairy cows. Anim Reprod. 2012;9:290–296. Available from: https://www.animal-reproduction.org
  54. López-Gatius F, Santolaria P, Yániz J, Fenech M, López-Béjar M. Risk factors for postpartum ovarian cysts and their spontaneous recovery or persistence in lactating dairy cows. Theriogenology. 2002;58(8):1623-1632. doi:10.1016/s0093-691x(02)01046-4
  55. Opsomer G, de Kruif A. Metritis and endometritis in high yielding dairy cows. Vlaams Diergeneeskundig Tijdschrift. 2009;78(2). doi:10.21825/vdt.87500
  56. Onyango J. Cow postpartum uterine infection: A review of risk factors, prevention and the overall impact. 2014. Available from: https://www.researchgate.net
  57. Amin RU, Bhat GR, Ahmad A, Swain PS, Arunakumari G. Understanding patho-physiology of retained placenta and its management in cattle – a review. Vet Clin Sci. 2013. Available from: www.jakraya.com/journal/vcs
  58. Walsh SW, Williams EJ, Evans ACO. A review of the causes of poor fertility in high milk producing dairy cows. Animal Reproduction Science. 2011;123(3-4):127-138. doi:10.1016/j.anireprosci.2010.12.001
  59. De Vliegher S, Fox LK, Piepers S, McDougall S, Barkema HW. Invited review: Mastitis in dairy heifers: Nature of the disease, potential impact, prevention, and control. Journal of Dairy Science. 2012;95(3):1025-1040. doi:10.3168/jds.2010-4074
  60. Galvão KN. Uterine diseases in dairy cows: understanding the causes and seeking solutions. Anim Reprod. 2013;10(3):228–238. Available from: https://animal-reproduction.org
  61. Bruun J, Ersbøll AK, Alban L. Risk factors for metritis in Danish dairy cows. Preventive Veterinary Medicine. 2002;54(2):179-190. doi:10.1016/s0167-5877(02)00026-0
  62. Crowe MA, Hostens M, Opsomer G. Reproductive management in dairy cows - the future. Irish Veterinary Journal. 2018;71(1). doi:10.1186/s13620-017-0112-y
  63. Tucho TT. Review on retention of placenta in dairy cows and its economic and reproductive impacts. 2017. Available from: www.iiste.org
  64. Ghavi Hossein-Zadeh N. Effects of main reproductive and health problems on the performance of dairy cows: a review. Spanish Journal of Agricultural Research. 2013;11(3):718-735. doi:10.5424/sjar/2013113-4140
  65. Larson LL, Ishak MA, Owen FG, Erickson ED, Lowry SR. Relationship of physiological factors to placental retention in dairy cattle. Animal Reproduction Science. 1985;9(1):31-43. doi:10.1016/0378-4320(85)90039-9
  66. Patel RV, Parmar SC. Retention of fetal membranes and its clinical perspective in bovines. Sch J Agric Vet Sci. 2016;3(2):111–6. Available from: http://saspjournals.com/sjavs
Support