Ayurveda is science of life and its main aim is to maintain healthy status of healthy living being, i.e., prevention of disease and treatment of disease. As per Ayurvedic science, sharir is made up of dosha, dhatu, updhatu and mala. Twacha is considered as updhatu of mamsa dhatu. Twacha is one among the five gyanendriyas having its perception as mentioned with their respective diseases.In Ayurvedic classics, various opinion regarding twacha uttapati, twacha stara and associated disorders are mentioned. This article lays emphasis on the known and the lesser known functions of twacha, its correlation with skin with special reference to anatomical and physiological aspect. This article describes twacha in all respects of kriyasharir (i.e., as an indriya and its role in sensation of touch, its doshic composition and its function) and Rachna sharir (i.e. structure, origin, types etc). Since description of twacha and its thickness is present in both the sciences, so an attempt is made in this article to correlate and compare twacha with skin (integument). Keywords: Ayurveda, Dosha, Dhatu, Updhatu, MalaCite this ArticleGupta GK, Devi G. A Comparative Study of Twacha Shareer with Skin (Integument). Research and Reviews: A Journal of Ayurvedic Science, Yoga and Naturopathy. 2018; 5(3): 7–12p