Research and Reviews: A Journal of Toxicology
Volume 14, Issue 2 (2024)
Table of contents
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Toxicology-Focused Development and Validation of an RP-HPLC Technique for Quantifying Bempefoic Acid and Rosuvastatin in a Fixed-Dose Combination
Abstract: A straightforward, precise method was developed to simultaneously assess Bempedoic acid and Rosuvastatin in both bulk and tablet forms. Utilizing a DIKMA Spursil C18 column (4.6 mm x 250 mm, 3.0 μm), chromatography was conducted with a mobile phase comprising 30% phosphate buffer and 70% acetonitrile, flowing at 1 ml/min. Operating at ambient temperature, the optimized wavelength for detection was set at 240 nm, revealing retention times of 4.418 min …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 2, 2024 · pp. 1–9 Read article
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Toxicological Optimization and Assessment of Buccal Films Containing Felodipine Co-crystals to Enhance Bioavailability
Abstract: The preformulation study of felodipine was carried out and it was found that the drug is poorly water soluble. The co-crystals were prepared using three different co-formers sorbitol, ascorbic acid and oxalic acid. The solublity enhancement was observed in combination with sorbitol compared to other co-formers used. The characterization of co crystals was performed like PXRD, FTIR, SEM Analysis. XRD results indicates the amorphous form of the drug. The co-crystals …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 2, 2024 · pp. 10–29 Read article
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Role of Application of SWCR Guidelines in Management of Right Trochanter Pressure Injury (PI)
Abstract: A pressure injury refers to the localized death of tissue resulting from sustained pressure on the skin and underlying tissues. This damage is often compounded by shear forces or direct trauma to the skin. While terms like “decubitus ulcer,” “bedsore,” and “pressure sore” are commonly used interchangeably, they fail to capture the complexity of the condition as accurately as the term “pressure injury” does. The term “decubitus” originates from Latin, …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 2, 2024 · pp. 30–40 Read article
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Role of Low Level Laser Therapy (LLLT) in Healing of Electric Burns
Abstract: The objective of this case study is to evaluate the effectiveness of low-level laser therapy (LLLT) in treating scalp wounds caused by electric burns. A thorough examination of the scalp wound was conducted both before and after administering LLLT. The findings suggest that LLLT plays a beneficial role in the healing process of superficial ulcers. Specifically, the application of LLLT (as depicted in Figure 1) demonstrated promising results in facilitating …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 2, 2024 · pp. 39–44 Read article
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Oligomenorrhea: An Overview in Toxicology
Abstract: In the contemporary era characterized by a swift and cutthroat environment, numerous gynecological issues are on the rise owing to sedentary lifestyles, improper dietary patterns, and other factors. The interaction between physical and mental health significantly affects the menstrual cycle. According to data, a staggering 80% of women grappling with irregular menstrual cycles find themselves in the grips of Oligomenorrhea, constituting 19.3% of this demographic. In today’s fast-paced and competitive …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 2, 2024 · pp. 45–51 Read article