Research & Reviews: A Journal of Drug Design & Discovery
Volume 1, Issue 3 (2014)
Published
Table of contents
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Evaluation of the Effect of Manyabasti and Sarvangatailadhra in Manyagata vata (Cervical Spondylosis)
Abstract: Present clinical study was designed to assess the efficacy of Manyabasti and Sarvangatailadhara in reducing the sign and symptoms of cervical spondylosis. Total 11 patients of cervical spondylosis were registered in the OPD and IPD of Samadhan Panchakarma Hospital, Nagpur, India. They were subjected to the treatment schedule of 15 days. During this period Manyabasti was done for 15 min and Sarvangatailadhara for 30 min by the mixture of Arogya …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 1, Issue 3, 2014 · pp. 1–5 Read article
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Screening of Some Triterpenoids Isolated from Terminalia arjuna as Inhibitors of Angiotensin Converting Enzyme to Prevent Cardiovascular Diseases
Abstract: Natural products have been shown to present interesting biological and pharmacological activities and are used as chemotherapeutic agents. Plants have historically been used in treating cardiovascular diseases (CVD) and are recognized for their ability to produce secondary metabolites. Secondary metabolites obtained from different plants have been the starting material for designing different drugs. Many useful phytoconstituents have been isolated from Terminalia arjuna. Tannins and flavonoids are responsible for its anticancer …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 1, Issue 3, 2014 · pp. 12–19 Read article
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Analytical Study of An Ayurvedic Herbomineral Formulation: PunarnavaMandura
Abstract: PunarnavaMandura is a herbomineral formulation commonly used for Pandu roga, in which Mandurabhasma is used as a major ingredient along with powder of twenty herbals in specified proportion. In this study PunarnavaMandura was prepared with reference quoted in BhaishajyaRatnavali. Mandurabhasma was prepared by following the standard parameters of bhasma preparation. To keep similar therapeutic efficacy of a drug, standardization and analytical evaluation is compulsory. So, the prepared PunarnavaMandura was analyzed …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 1, Issue 3, 2014 · pp. 20–24 Read article
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Analysis of Docking Study on Protein Neprilysin (Neutral Endopeptidase) Inhibition for Anti-aging Treatment by Aloe Emodin and Aloe Emodin Carbonyl Derivative
Abstract: Attempts were made to perform comparative docking study of Aloe emodin and its derivative on Neprilysin (PDB code: 1R1J) by using VLife MDS software to ascertain the activity of both. From all the interactions (Hydrogen bond and vander waals) it was observed that, the common amino acids which interacts with the common ligand were ASN542A, ALA543A, ARG102A, ASN542A, VAL580A. The result showed that the AEC (–1790.15 KCal) showed high total …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 1, Issue 3, 2014 · pp. 6–11 Read article