Research & Reviews: A Journal of Bioinformatics
Volume 5, Issue 3 (2018)
Published
Table of contents
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Induced-Fit Molecular Docking and Pharmacokinetic Prediction Studies of Two Phenanthrene Compound Series as Potential Cyclooxygenase-2 (COX-2) and Lipoxygenase (LOX) Inhibitors: Edema Reducing Prospects of the Emerging Candidates
Abstract: The existing explorative study involved determining the anti-inflammatory potential of two inter-linked series of phenanthrene compounds against vital targets such as cyclooxygenase-2 (COX-2) (PDB ID: 3LN1) and lipoxygenase (LOX) (PDB ID: 1N8Q) by induced fit docking (IFD) technique, employing the Glide module of Maestro 9.1 software. In addition to it, the comprehensive pharmacokinetic parameters (all 33 critical aspects) were determined using the QikProp module. The study opened avenues for developing …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 5, Issue 3, 2018 · pp. 1–8 Read article
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Non-parametric Survival Techniques with Improved Weight
Abstract: Generally, in most of the studies all the subjects could not attain the event of interest within the time period, which results in censoring, also sometimes leads to the situation of heavy censoring. In the case of heavy censoring, the conventional Kaplan-Meier estimator overestimates the survival function. To overcome this, a new weight is designed by accounting the length of the survival time and censoring rate for each time interval …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 5, Issue 3, 2018 · pp. 19–29 Read article
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In Silico Comparative Modeling of Maturase K Protein in Cymbopogon martinii Plant
Abstract: In recent years, due to environmental, health and safety concerns, there has been an increasing interest in replacing synthetic compounds with natural products. Essential oils of aromatic plants are of great interest among natural products because of their relatively low or negligible toxicity and high volatility and biodegradability.Cymbopogon martinii (gramineae) is a medicinal and aromatic plant of great importance and rich in essential oils. Essential palmarosa-derived oils have shown exceptionally …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 5, Issue 3, 2018 · pp. 30–36 Read article
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Lexical Semantic Organization in Visually Challenged and Neurotypical Children
Abstract: The words in the lexicon are arranged in a specific pattern. The words belonging to the same lexical category is assumed to be arranged together and this notion is termed as taxonomic arrangement, while the second view believes that the words, which share a common theme, are arranged together, and this kind is arrangement is termed as thematic. Typically, developing children show a developmental trend and this trend as proven …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 5, Issue 3, 2018 · pp. 37–41 Read article
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Protein Modeling and Drug Docking Studies on Potential Protein Target (E. coli–dosP) and Compound Aldehyde (Sumatriptan) using Bioinformatics Tools
Abstract: The aim of the present in silico studies is to find out the potential protein target in stationary phase-induced biofilm regulator (E. coli–dosP) and deliver the 3D structure and to introduce the best inhibitors of aldehydes (Sumatriptan) using molecular drug docking techniques. The potential chemical compound, Aldehyde (Sumatriptan) was retrieved from NCBI PubChem compound database and converted into the 3D structure using online smiles translator and finally docking studies were …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 5, Issue 3, 2018 · pp. 9–18 Read article