STM Journals Peer-reviewed research from Consortium e-Learning Network

Journal of Catalyst & Catalysis

Direct and rapid synthesis of amides from carboxylic acids under solvent free condition using Clay based Heterogeneous recyclable catalyst

  1. Rumaisa Jan
  2. Mohamad Yousf
  3. Fayaz A. Butt
  4. Akhter H. Malik
  5. Gh. Jeelani Mir
  6. Bashir A. Dar

Abstract

Direct condensation of Carboxylic Acids and Amines has resulted in a highly simple and practical technique for the synthesis of amides. Fe-Al clay catalyst was used in the solvent-free, microwave-irradiated amide synthesis. Only a small amount of the catalyst was needed to produce products in very short of time with a good yield. The catalyst was easy to separate and could be recycled several times with negligible loss of catalytic activity even after 6 cycles. The products were purified by crystallization rather than column purification. In a solution devoid of bases, solvents, and ligands, the heterogeneous nature of the catalyst provides support for a practical and ecologically friendly procedure.
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