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Journal of Catalyst & Catalysis Review Article

Catalyst: Free Synthesis of Bioactive Molecules via Green Chemical Principles

  1. Rizwan Arif Department of Chemistry School of Basic and Applied Sciences, Lingaya’s Vidyapeeth bFaridabad, ,
  2. Neha Sahu Department of Chemistry School of Basic & Applied Sciences, Lingaya’s Vidyapeeth, Faridabad, .

Abstract

This study explores the catalyst-free synthesis of bioactive molecules, emphasizing the application of green chemical principles. Traditional synthetic methods often rely on hazardous reagents, solvents, and metal catalysts, which can pose significant environmental and health risks. In contrast, the catalyst-free approach leverages benign reaction conditions, such as solvent-free systems, ambient temperature, and pressure, to achieve efficient and selective transformations. We present a comprehensive investigation into various bioactive molecule syntheses, including pharmaceuticals, agrochemicals, and natural product derivatives, demonstrating the feasibility and advantages of catalyst-free methods. Key reactions, such as cyclizations, condensations, and functional group transformations, are optimized under green conditions. The outcomes highlight significant improvements in atom economy, energy efficiency, and waste reduction, aligning with the twelve principles of green chemistry. Experimental results reveal that the absence of catalysts not only simplifies purification processes but also enhances the overall sustainability of the synthesis. Furthermore, mechanistic studies provide insights into the reaction pathways and enable the rational design of new catalyst-free transformations, expanding the scope of this approach for the development of sustainable and eco-friendly synthetic methodologies.

Keywords

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