Adaptogenic Action of Different Dosage Forms of Guduchi with Special Reference to Learning and Memory

Shilpa Govind Patil; Anshuman Trigunayat; Anand Kumar Chaudhary

Abstract

The effect of three dosages forms of Guduchi (Satva 125 mg/kg, Ghana, 50 mg/kg, Churna 200 mg/kg) are compared with control and Piracetam (500 mg/kg) treated experimental animals in morris water maze test and passive avoidance test. The aim of the paper is to evaluate the nootropic effect of three dosages forms of Guduchi. Guduchi Satva, Ghana and Churna was prepared following the classical methods. For experimental study, animals were divided into five groups of six animals each, comprising both male and female in each group as Group A, B, C, D and E who received CMC, piracetam, Satva, Ghana and Churna respectively. Statistical analysis shows one-way ANOVA test followed by post hoc Tucky & Kramer multiple comparison test using graph pad prism 6 was used for statistical analysis Piracetam, Guduchi satva and Ghana significantly reversed spatial loss of learning and memory in morris water maze test and significantly reversed the deficit of spatial learning and memory by increase in step through latency in passive avoidance test. This suggests the nootropic effect of Guduchi satva and Ghana as same as that of the piracetam.

Abstract

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