International Journal of Bioinformatics and Computational Biology Review Article

A Systematic Review on The Role of Artificial Intelligence in Assisted Reproductive Technology

  1. Latika Department of CSE;Jagannath University
  2. Dr. Renuka Arora Department of CSE; Jagannath University

Abstract

Artificial Intelligence (AI) has significantly transformed Assisted Reproductive Technology (ART) over the past five years, enhancing diagnostic accuracy, treatment personalization, and overall success rates. AI-driven algorithms and machine learning models have been integrated into various aspects of ART, including sperm selection, embryo grading, and predicting implantation success. Deep learning techniques have improved image-based embryo assessment, reduced human subjectivity and increased efficiency. Additionally, AI-powered predictive analytics have helped optimize ovarian stimulation protocols and identify potential causes of infertility. AI has proved its worth in all most all sectors, it has the potential to bring a boom in Reproductive field as well as AI can help to analyze the data and can predict results which may help the women who wish to conceive through ART techniques. This will improve overall health, mental condition and create an understanding between patient and doctor, which will result increase in success rate of pregnancy achieved through ART methods. This review highlights the role of Artificial Intelligence in ART like IUI, IVF and ICSI, discusses its impact on clinical outcomes, and explores future possibilities in the field. Paper aims to focus on role of AI in ART techniques, AI in ART in low- and middle-class families, embryo selection using AI, sperm selection using AI. Paper also gives a review of factors for the success of ART through AI with focus on providing personalized experience through AI to the women patients. Along with this role of AI in ICSI and IUI is also reviewed. While AI has shown great promise in improving reproductive success, ethical considerations and regulatory frameworks remain crucial to ensure safe and effective implementation in clinical practice.

Keywords

References (24)

  1. M Raimundo, P Cabrita, “Artificial Intelligence at Assisted Reproductive Technology”, International Conference on Enterprise Information Systems / ProjMAN - International Conference on Project Management/ HCist - International Conference on Health and Social Care Information Systems and Technologies 2020.
  2. Rutvij J Dala, Sahil Gupta, Akanksha P Mishra,” Artificial Intelligence in Assisted Reproductive Technology: Present and Future”, Int J Infertil Fetal Med 2020;11(3):61– 64.
  3. Darren J X Chow, Philip Wijesinghe , Kishan Dholakia and Kylie R Dunning,” Does artificial intelligence have a role in the IVF clinic?”, Published by Bioscientifica Ltd, 2021
  4. Simon Hanassab Tom W. Kelsey , Ali Abbara, Arthur C. Yeung Margaritis Voliotis, Krasimira Tsaneva- Atanasova , Geoffrey Trew, Scott M. Nelson, Thomas Heinis and Waljit S. Dhillo,” The prospect of artificial intelligence to personalize assisted reproductive technology”, npj Digital Medicine (2024) 7:55 ; https://doi.org/10.1038/s41746-024- 01006-x.
  5. Tendai M. Chiware Karel Blondeel, Nathalie Vermeulen, Roy Farquharson, James Kiarie, Kersti Lundin, Thabo Christopher Matsaseng, Willem Ombelet and Igor Toskin,” IVF and other ART in low- and middle- income countries: a systematic landscape analysis”, Human Reproduction Update, Vol.27, No.2, pp. 213–228,
  6. Kadrina Abdul Latif Abdullah, Tomiris Atazhanova,· Alejandro Chavez-Badiola, · Sourima Biswas Shivhare,” Automation in ART: Paving the Way for the Future of Infertility Treatment”, Reproductive Sciences (2023) 30:1006–1016.
  7. Mikkel Fly Kragh ,Henrik Karstoft,” Embryo selection with artificial intelligence: how to evaluate and compare methods?”, Journal of Assisted Reproduction and Genetics (2021) 38:1675–1689.
  8. Rocío Nuñez-Calonge, Nuria Santamaria, Teresa Rubio, and Juan Manuel Moreno,” Making and Selecting the Best Embryo in In vitro Fertilization”, Archives of Medical Research 55 (2024) 103068.
  9. Michael Anis Mihdi Afnan , Yanhe Liu, Vincent Conitzer Cynthia Rudin, Abhishek Mishra, Julian Savulescu, and Masoud Afnan, “Interpretable, not black-box, artificial intelligence should be used for embryo selection”, Human Reproduction Open, pp. 1, 2021.
  10. Salih , C. Austin V. Smith ,R.R. Warty ,B.Vollenhoven ,C.Tiktin and F. Horta ,” Embryo selection through artificial intelligence versus embryologists: a systematic review”, Human Reproduction Open, 2023, 2023(3), hoad031.
  11. Zanettoullis AT, Mastorakos G, Vakas P, Vlahos N, Valsamakis G. Effect of Stress on Each of the Stages of the IVF Procedure: A Systematic Review. International Journal of Molecular Sciences. 2024;25(2):726. doi:10.3390/ijms25020726
  12. McMahon , ,K.Hammarberg ,S.Lensen ,R.Wang, ,B.W.Mol , andB.J.N. Vollenhoven ,” What do women undergoing invitro fertilization (IVF) understand about their chance of IVF success?”, HumanReproduction, 2024, 39(1), 130–138.
  13. Yangcheng Yao, Wenjuan Liu, Xiqian Zhang, Nianjun Su, Li Huang, Yingqi Nong, Xiaomin Xiao and Fenghua Liu,” Normal weight obesity is associated with lower AFC and adverse IVF outcomes”, Frontiers in Endocrfinology, 22 feb 2024.
  14. Kadrina Abdul Latif Abdullah, Tomiris Atazhanova , Alejandro Chavez-Badiola· Sourima Biswas Shivhare,” Automation in ART: Paving the Way for the Future of Infertility Treatment”, Reproductive Sciences (2023) 30:1006–1016.
  15. Chenyi Zhong, Liusijie Gao, Li Shu, Zhen Hou, Lingbo Cai, Jie Huang, Jiayin Liu and Yundong Mao, ”Analysis of IVF/ICSI Outcomes in Endometriosis Patients With Recurrent Implantation Failure: Influence of Cumulative Live Birth Rate.
  16. Lynae M. Brayboy,· Alexander M. Quaas, “ The DIY IVF cycle—harnessing the power of deeptech to bring ART to the masses”, Journal of Assisted Reproduction and Genetics (2023) 40:259–263.
  17. Mostinckx, E. Goyens, S. Mackens, C. Roelens, L. Boudry Blockeel ,and M.DeVos, Brussels IVF, Universitair Ziekenhuis Brussel,” Clinical outcomes from ART in predicted hyper responders: in vitro maturation of oocytes versus conventional ovarian stimulation for IVF/ICSI”, Human Reproduction, 2024, 39(3), 586–594
  18. Shimona Lai , Rui Wang Inge Custers , Madelon van Wely , Angelique J. Goverde , Michael Costello4, Cindy Farquhar, Alexandra J. Bensdorp, , Hossam Elzeiny , Ben W. Mol , and Wentao Li ,” IVF versus IUI with ovarian stimulation for unexplained infertility: a collaborative individual participant data meta-analysis”, Human Reproduction Update, 2024, 30(2), 174–185.
  19. Manesh KumarPanner ,Selvam , Ajaya Kumar Moharana, Saradha Baskaran Matthew C. Hudnall andSuresh C.Sikka,” Current Updates on Involvement of Artificial Intelligence and Machine Learning in Semen Analysis,” Machine Learning in Semen Analysis. Medicina 2024, 60,https://doi.org/10.3390/ medicina60020279.
  20. Nikit Venishetty , Marwan Alkassis and Omer Raheem,” The Role of Artificial Intelligence in Male Infertility: Evaluation and Treatment: A Narrative Review”, Uro | An Open Access Journal from MDPI, January 2024.
  21. Kawale SP, Ambad R, Jha RK, Jha RK, Gaikwad A. Role of Artificial Intelligence in ICSI (Intra-Cytoplasmic Sperm Injection) &IUI (Intra-Uterine Insemination). E3S Web of Conferences. 2024;491:03019. doi:10.1051/e3sconf/202449103019
  22. Montjean D, Godin Pagé MH, Pacios C, Calvé A, Hamiche G, Benkhalifa M, et al. Automated Single-Sperm Selection Software (SiD) during ICSI: A Prospective Sibling Oocyte Evaluation. Medical Sciences. 2024;12(2):19. doi:10.3390/medsci12020019
  23. Gongora A and Barajas,” A New Perspective on Sperm Analysis Through Artificial Intelligence: The Path Toward Personalized Reproductive Medicine”, Annals of Clinical and Medical Case Reports, ISSN 2639- 8109 Volume 14.
  24. Mapari SA, Shrivastava D, Bedi GN, Pradeep U, Gupta A, Kasat PR, et al. Revolutionizing Reproduction: The Impact of Robotics and Artificial Intelligence (AI) in Assisted Reproductive Technology: A Comprehensive Review. Cureus. 2024. doi:10.7759/cureus.63072