2 publications

• Published Subscription 17 May 2019

  In Silico Designing of Triazolothiadiazine as Anticancer Agents

  By Monika Kakadiya, Nidhi Joshi, Malleshappa Noolvi, Uttam A. More

  Abstract: Cancer is irregular growth of cells and formation of tumor. There are approximately 9.6 million death reported globally. It is caused by physical or genetic factor. There are various targets for the inhibition of growth of cancerous cells. Inhibition of colchicines binding site of tubulin is promising target in field of cancer management. In this study, we designed 25 novel thiazole and triazolothiadiazine derivatives as colchicine binding site inhibitors and …

  Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 6, Issue 1, 2019 · pp. 10–20 Read article →

• Published Subscription 17 Jan 2019

  Exploring Molecular Structural Requirement of Acetylcholinesterase Inhibitors Using Molecular Docking Study

  By Uttam A. More, Vidhi B Rahevar, Malleshappa N Noolvi

  Abstract: To explore the molecular structure requirement of acetyl-cholinesterase inhibitors, we used some flavonoid derivatives and calculated its binding interaction with acetylcholinesterase enzyme using 1EVE PDB. Flavonoids are one of the largest class and plant secondary metabolites known to have variety of biological activity for human wellbeing. Also reported its acetylcholinesterase inhibitory potency by various researchers. To know the properties and selection of flavonoids, we were used databases through Google Scholar, …

  Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 5, Issue 3, 2018 · pp. 20–34 Read article →