1 publication

• Published Subscription Original Research 16 Jun 2026

  Design and Evaluation of Thermo-Responsive Poly(N-isopropylacrylamide)-Based Polymeric Nanoparticles for Temperature-Triggered Intratumoral Release of Doxorubicin in Solid Tumors

  By Kavya D, Khanderao Rajaram Jadhav, Suvarna Manoj Bhadane, Sujit Appasaheb Jadhav, Mohit Kumar, Manisha S Nangude, Josef Yakin, Vikrant Kisanrao Nikam, Akshay Kumar K S

  Abstract: Thermo-responsive polymeric systems have emerged as promising platforms for targeted intratumoral drug delivery in cancer therapy. This study aimed to develop and evaluate poly(N-isopropylacrylamide) (PNIPAM)-based polymeric nanoparticles as intelligent carriers for temperature-responsive delivery of doxorubicin (DOX) to solid tumors. Nanoparticles were synthesized via free radical polymerization using N-isopropylacrylamide as a thermoresponsive monomer and N,N′-methylenebisacrylamide as a crosslinker, forming a stable network with a tunable lower critical solution temperature (LCST).The optimized …

  Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 · pp. 159–168 Read article →