2 publications

• Published Subscription 21 Jan 2015

  Formulation Development and Evaluation of Sublingual Tablets of Enalapril Maleate Using Co-processed Superdisintegrants

  By Ankita Patel, Nikita Gajera, Pranav Shah, Shailesh Shah

  Abstract: Enalapril Maleate is anti-hypertensive drug and its oral bioavailability is 40%. Sublingual tablets of Enalapril Maleate were prepared to improve its bioavailability, to avoid pre-systemic metabolism and hepatic first pass elimination. Tablets were prepared by wet granulation technique using two different superdisintegrants KYRON-T-314 and INDION-414 in the different ratio (1:1, 1:2 and 2:1) by co-processing and physical mixing. FTIR (Fourier transform infrared spectroscopy) and DSC (differential scanning calorimetry) spectroscopic studies …

  Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 5, Issue 3, 2014 · pp. 24–39 Read article →

• Published Subscription 22 Apr 2014

  Formulation and Evaluation of Buccal Mucoadhesive Bilayered Tablets of Enalapril Maleate

  By Pranav Shah, Yogita Gadhethariya, Shailesh Shah

  Abstract: The buccal mucoadhesive bilayered tablets of Enalapril Maleate were fabricated with objective of avoiding first pass metabolism and prolonging the duration of action. The tablets were prepared by wet granulation wherein, one layer comprised of drug and bio adhesive polymer, whereas second layer consisted of drug free backing layer of ethyl cellulose. Bioadhesive polymers like Carbopol 934P and one either of three HPMC K4M/ HPMC K15M/ HPMC K100M were employed …

  Published in Trends in Drug Delivery · Vol. 1, Issue 1, 2014 · pp. 1–15 Read article →