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6 publications

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    Spectrophotometric Method for the Estimation of Aciclovir in Bulk Drug

    By S. Shanmugam, Valarmathi S., Ravichandran V., Satheesh Kumar S, Shanmugasundaram P

    Abstract: Aciclovir gives antiviral activity; one, new, simple, accurate, rapid, economical and precise procedure for spectrophotometric estimation of aciclovir in bulk drug. Aciclovir was estimated at 254 nm in 0.1 M sodium hydroxide, at 254 nm in 0.1 M hydrochloric acid, and at 254 nm in 7.4 phosphate buffers. The linearity range was found to be 5–30 µg/ml. The molar absorptivity was found to be 9.376x10 in 0.1 M sodium hydroxide, …

    Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 2, Issue 3, 2015 · pp. 1–3 Read article

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    Spectrophotometric Method for the Estimation of Levosulpiride in Bulk Drug and Formulations

    By S. Shanmugam, Babu R., Ravichandran V.

    Abstract: Levosulpiride having D2-dopamine receptor antagonistic activity gives ant depressive and antiulcer effect. There are three new simple accurate, rapid, economical and precise procedures for spectrophotometric estimation of Levosulpiride in bulk and pharmaceutical formulation. Levosulpiride was estimated at 291.5 nm in 0.1 N NaOH, 290 nm in 0.1 N HCl and 292.5 nm in 6.8 phosphate buffer. Linearity range was found to be 10–50 µg/mL in all the three methods. The …

    Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 2, Issue 1, 2015 · pp. 19–23 Read article

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    Formulation Development and Evaluation of Opthalmic Ocusert Containing Timolol Maleate

    By S. Shanmugam, T. Vetrichelvan

    Abstract: The aim of formulating timololmaleate occusert was to prolong the drug residence time after ocular administration to achieve the controlled release of drug. Timolol maleate is an antiviral agent and it is used in the treatment of viral infections like herpes simplex infections. Ocular inserts were prepared by solvent casting method. Drug reservoir and rate controlling membrane were prepared using different hydrophilic and hydrophobic polymers respectively with polyethylene glycol 400 …

    Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 4, Issue 1, 2017 · pp. 8–12 Read article

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    Drug Profile: Mebeverine Hydrochloride

    By S. Shanmugam, T. Ayyappan, T. Vetrichelvan

    Abstract: Irritable bowel syndrome (IBS) is the most prevalent functional gastrointestinal disorder noted in the general population worldwide. Its chronic nature, signs and symptoms which vary periodically from mild to severe have many negative effects on the quality of life for the sufferer; therefore, the appropriate treatment of these patients is highly important. Patients should be informed by their doctors that the nature of the disease is benign, and educated on …

    Published in Trends in Drug Delivery · Vol. 3, Issue 3, 2016 · pp. 20–22 Read article

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    Study of Price Variation of Anti-infective Eye Preparations

    By S. Shanmugam, T. Vetrichelvan, T. Ayyappan

    Abstract: To analyze the percentage cost variations among different brands of commonly prescribed ophthalmic drugs. The cost of different brands of commonly used ophthalmic drugs was sorted out by referring the latest Current Index of Medical Specialities, Indian Drug Review and Retail drug store. The cost of five dosage forms in INR of each brand, cost ratio and percentage cost variation ware calculated. Our study findings showed a very high fluctuation …

    Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 5, Issue 2, 2018 · pp. 10–12 Read article

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    Ocular Inserts: An Overview

    By S. Shanmugam, T. Vetrichelvan, S. Valarmathi

    Abstract: Ocular inserts are sterile preparations which are to be placed into cul-de-sac or conjuctival sac. The major aim of ocular insert is to maintain a therapeutic level at the site of action for prolonged period of time. The therapeutic efficacy of an ocular drug can be greatly improved by prolonging its contact with the corneal surface. Ocular insert gives several advantages like increased ocular residence time, drug release at a …

    Published in Trends in Drug Delivery · Vol. 4, Issue 2, 2017 · pp. 20–22 Read article

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