1 publication

• Published Subscription 5 Apr 2019

  A Single-domain Antibody Cross-reacts with Lipopolysaccharide from Diverse Gram-negative Bacteria

  By Ajit Singh, S. Banerjee

  Abstract: Gram-negative bacterial sepsis and endotoxemia are the leading causes of morbidity and mortality in animals and humans worldwide, and attempts have continued to design rational therapies. Endotoxin/lipopolysaccharide (LPS)-neutralizing polyclonal and monoclonal antibodies have been produced, but are not free from problems. Single-domain antibodies (dAbs), constructed from the camelid and the shark ‘heavy chain antibodies’ by phage display technology possess favorable features for in vivo applications. The objective of this study …

  Published in Research and Reviews : A Journal of Immunology · Vol. 6, Issue 2, 2016 · pp. 29–37 Read article →