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Design, Synthesis and Pharmacological Evaluation of Pyrazoline Substituted Benzimidazole Derivatives as Antibacterial and Antifungal AgentsBy Remya R S
Abstract: Background: Benzimidazoles are important heterocyclic compounds possessing a variety of biological activities such as anticancer, antioxidant, antiinflammatory, analgesic, anti-viral, anti-bacterial, anti-fungal and hypoglycemic activities. Pyrazolines are used as antitumor, immunosuppressive, antibacterial and anti tubercular agents. Aim : The present research focused on incorporating pyrazoline nucleus into benzimidazole nucleus to form a potent antibacterial and antifungal agent. Method: The in silico design of novel pyrazoline substituted benzimidazole derivatives was done using …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 11, Issue 3, 2020 · pp. 29–41 Read article →