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Monophase Solution for Enhancing Solubility and Dissolution of Ezetimibe by Spray Dried MicroparticleBy Mudit Dixit, Parthasarthi Keshavarao Kulkarni, R. Narayana Charyulu
Abstract: The aim of the present study was to improve the solubility and dissolution rate of Ezetimibe by preparing crystals by spray drying technique using Isopropyl alcohol (IPA) and water as solvent system. Ezetimibe crystals were produced by spray drying using IPA as solvent to enhance solubility and dissolution rate. The prepared crystals were evaluated for solubility and in vitro dissolution. The prepared formulations were characterized by differential scanning calorimetry (DSC), …
Published in Trends in Drug Delivery · Vol. 1, Issue 3, 2014 · pp. 30–36 Read article →