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An in Silico Study of Selected Compounds from Garcinia spp. to Fight against Multidrug Resistant BacteriaBy Bonashree Phukan, Partha Sarathi Borah, Seema Barman, Minakshi Puzari, Mohan Sharma, Pankaj Chetia
Abstract: AbstractBackground: Antibiotic resistant bacteria have emerged as a global threat. They have limited the number of available treatment options. New Delhi Metallo-beta-lactamase-1 (NDM-1) mediated drug resistance and efflux pump mediated drug resistance are among the major mechanisms associated with multidrug resistance.Objective: In our study, potential NDM-1 inhibitors as well as efflux pump inhibitors were identified through reverse chemogenomics from Garcinia spp. to deal with multidrug resistant bacteria. Method: Selected compounds …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 4, Issue 2, 2017 · pp. 1–4 Read article →