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2 publications

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    In Silico Assessment of Drug like Properties of Some Thiadiazole and Oxadiazole Derivatives as HDAC Inhibitors

    By PARIN Sidat SIDAT, Janvi V Shah, Feni B. Shah, Aishiq H Ganie

    Abstract: Purpose: To investigate in silico the drug-like properties of some thiadiazole and oxadiazole derivatives as HDAC inhibitors. Methods: We used Chemdraw Ultra 11.0 to redraw all chemical structures. Furthermore, some applications, such as Bio-Loom for Windows - version 1.5, Molinspiration Property Calculator, and ACD/I-LAB, were used to forecast the drug-like properties of thiadiazole and oxadiazole derivatives, including relative molecular mass (MW), partition coefficient log P (cLog P), number of hydrogen …

    Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 9, Issue 2, 2022 · pp. 1–13 Read article

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    In Silico Study of Histone Deacetylase Inhibitor as Anticancer Agents

    By PARIN Sidat SIDAT, Malleshappa N. Noolvi, Vishal G. Beldar, Azmin M. Mogal

    Abstract: The clinical selective histone deacetylase inhibitor vorinostat is most commonly used for the treatment of lymphoma and solid tumor and has been preventing lives worldwide. Vorinostat is used in both treatment and prevention of lymphoma and other tumors. Based on these for current study some vorinostat derivatives with thiadiazole moiety containing derivatives have been designed for in silico study. For present work, the already selected study was against histone human …

    Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 6, Issue 2, 2019 · pp. 6–23 Read article

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