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• Published Subscription 5 Apr 2019

  The Ames Test in Twenty-first Century

  By Myriam Arriaga-Alba, Regina Montero_Montoya, Javier J. Espinosa Aguirre

  Abstract: Since the 19th century, industrial development has increased exposure to mutagens and possible carcinogens. In order to avoid these health risks, several techniques have been developed to recognize genotoxins. In the 1970s, Dr. Bruce Ames and colleagues, studying the histidine operon of Salmonella typhimurium, observed that histidine (−) auxotroph mutants were reverted to histidine (+) upon exposure to a mutagen. The researchers further observed that known carcinogens were mutagenic to …

  Published in Research and Reviews: A Journal of Toxicology · Vol. 2, Issue 1, 2012 · pp. 23–37 Read article →