10 publications
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Formulation and Evaluation of Transdermal Drug Delivery of PiroxicamBy Mudit Dixit, P. K. Kulkarni, R. Narayana Charyulu
Abstract: The aim of the present study was to formulate transdermal films loaded with Piroxicam (PX). Transdermal films were prepared by using sodium alginate (SA) and xanthan gum (XG) as biopolymers by varying the blend ratios viz., 10:0, 8:2, 6:4, 4:6 and 2:8 (w/w %) through solution casting method. The drug loaded membranes were evaluated for thickness, tensile behaviours, and content uniformity. In-vitro diffusion was determined by Franz diffusion cell. Piroxicam …
Published in Trends in Drug Delivery · Vol. 1, Issue 2, 2014 · pp. 8–13 Read article →
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Characterization of Tabletting Properties of Mango GumBy Mudit Dixit, Selvam P. R., Kulkarni P. K., Charyulu R. N.
Abstract: The aim of the study is to elucidate the physical, thermal, sorption, and functional properties of a mango gum obtained from the stem of Mangifera indica were characterized viz. elemental analysis, Fourier transmittance infrared, particle size analysis, thermogravimetric analysis, differential scanning colorimetry, scanning electron microscopy, and X-ray powder diffraction. Mango gum had a glass transition temperature (Tg) and melting peak of 90 and 318.795°C, respectively. This material showed a 14.59% …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 1, Issue 2, 2014 · pp. 22–30 Read article →
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Preparation of Oral Gels Containing Ethanolic Extract of anacardiumoccidentale L and CharacterizationBy Mudit Dixit, Prashant Nayak, Sofia Sunny, Tripthi Shetty, Vineetha K
Abstract: The anti-microbial activity of gel containing Anacardiumoccidentale L. leaf extract was investigated. A total of four formulations (ST1–ST4) and a control (without leaf extract) were prepared. All the formulations were evaluated for physical appearance and physical properties of gel like pH, viscosity, spreadability and extrudability. The results of all the physical parameters of the gel were found to be within the limits. All the four formulations including control were evaluated …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 2, Issue 3, 2015 · pp. 16–20 Read article →
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Formulation and In vitro Evaluation of Oral Fast Dissolving Tablets of A Novel Antidepressant Drug by Using Camphor As A Subliming AgentBy Mudit Dixit, CR Narayana, Nayak P, Dixit M
Abstract: The purpose of the present investigation is to formulate fast dissolving tablets of Venlafaxine HCl, a novel antidepressant by direct compression method using camphor as subliming agent in the three different concentrations of 2%, 5% and 10%. Croscarmellose, tulsion-414 and sodium starch glycolate were used as superdisintegrants in two different concentrations of 5% and 10%. The drug-excipients compatability was ruled out through FTIR studies. A total of six formulations were …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 2, Issue 3, 2015 · pp. 12–18 Read article →
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Development and Characterization of Mucoadhesive Microspheres Containing a Model Antidiabetic DrugBy Mudit Dixit, R. Narayana Charyulu, Sompalli Prashanthi, Nisha G. Shetty
Abstract: The present work was envisaged to reduce the dosing frequency and improve patient compliance by designing and evaluating sustained release mucoadhesive (SRM) microspheres of metformin hydrochloride (MH) for an effective control of diabetes type-2. Microspheres were prepared by emulsification solvent evaporation method using sodium alginate, carbopol 934P (CP), and sodium carboxy methyl cellulose (SCMC) as a mucoadhesive polymers. The microspheres exhibits good mucoadhesive properties and showed high drug entrapment efficiency. …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 2, Issue 2, 2015 · pp. 12–19 Read article →
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A Brief Note on Different Concept of BiowaiverBy Mudit Dixit, Rohit Dixit, Vasanth Samaga, Ganapayya Bairy, Ajay Bairy
Abstract: The aim of the present work was to understand the concept of to waive a complete and systemic bioequivalence (BE) study. Biowaiver or request for a biowaiver is a fast track approach to boost the drug development process. Over the past three-four years, the biowaiver market has shown greater number of biowaiver submissions and the wider use of in-vitro permeability study. Biowaiver is a beneficial approach for getting approval of …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 3, Issue 3, 2016 · pp. 22–30 Read article →
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Preparation and Characterization of Solid Dispersion of TenoxicamBy Mudit Dixit, R. Narayana Charyulu, Amit Patil, C.S. Shastry
Abstract: The aim of the present study was to prepare solid dispersions of a poorly water-soluble drug Tenoxicam in Polyvinylpyrrolidone (PVP), prepared by spray-drying techniques. The physicochemical properties of the solid dispersion and drug-polymer interactions were characterized by DSC, FT-IR, XRD and SEM. Tenoxicam was found amorphously dispersed in solid dispersion systems with the drug to polymer weight ratio of 1:3. Dissolution profile of the prepared solid dispersion was compared with …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 2, Issue 1, 2015 · pp. 23–29 Read article →
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Preparation and Characterization of Fenofibrate Freeze-Dried CrystalsBy Mudit Dixit, R. Narayana Charyulu, Amit Patil, Chakrakodi S. Shastry
Abstract: The present research work was aimed to prepare fenofibrate freeze-dried crystals using poloxamer by freeze-drying technique. Fenofibrate crystals containing poloxamer were prepared by freeze drying using acetone and water as solvent system. The prepared formulations containing drug and poloxamer were evaluated for solubility and in-vitro dissolution. The prepared formulations were characterized by DSC, FT-IR, XRD and SEM. Dissolution profile of the prepared freeze-dried crystals was compared with its physical mixture …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 2, Issue 1, 2015 · pp. 16–22 Read article →
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Microsponges: A Novel Approach for Transdermal Delivery of TolnaftateBy Mudit Dixit, Charyulu RN, Avril Mathias
Abstract: The present study was aimed at preparing tolnaftate-loaded microsponges and incorporating them into a topical formulation. Microsponge delivery system was chosen as it can increase the concentration of the drug on the superficial layer of the skin. Microsponges were prepared by quasi-emulsion technique. The studies like drug entrapment efficiency showed that the drug was completely entrapped within the pores of the microsponges. The microsponges were incorporated into the optimized carbopol …
Published in Trends in Drug Delivery · Vol. 2, Issue 2, 2015 · pp. 38–46 Read article →
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Monophase Solution for Enhancing Solubility and Dissolution of Ezetimibe by Spray Dried MicroparticleBy Mudit Dixit, Parthasarthi Keshavarao Kulkarni, R. Narayana Charyulu
Abstract: The aim of the present study was to improve the solubility and dissolution rate of Ezetimibe by preparing crystals by spray drying technique using Isopropyl alcohol (IPA) and water as solvent system. Ezetimibe crystals were produced by spray drying using IPA as solvent to enhance solubility and dissolution rate. The prepared crystals were evaluated for solubility and in vitro dissolution. The prepared formulations were characterized by differential scanning calorimetry (DSC), …
Published in Trends in Drug Delivery · Vol. 1, Issue 3, 2014 · pp. 30–36 Read article →