2 publications

• Published Subscription 28 Aug 2019

  DESIGNING OF COUMARIN ANALOGS: A NEW INSIGHT AS ENOL ACYL CARRIER PROTEIN REDUCATSE INHIBITORS

  By Monika Kakadiya, MOGAL AZMIN, MALLESHAPPA N. NOOLVI

  Abstract: Tuberculosis was almost certainly the leading cause of death in Europe and the United States in recorded history, although because of the multifarious forms of the disease. Based on literature we have designed coumarin linked with thiadiazole derivatives as antitubercular agents. To determine structural requirements, we carried out molecular docking study in which we found that our designed molecule have similar binding with enoyl acyl carrier protein reductase (InhA). The …

  Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 6, Issue 2, 2019 · pp. 1–5 Read article →

• Published Subscription 17 May 2019

  In Silico Designing of Triazolothiadiazine as Anticancer Agents

  By Monika Kakadiya, Nidhi Joshi, Malleshappa Noolvi, Uttam A. More

  Abstract: Cancer is irregular growth of cells and formation of tumor. There are approximately 9.6 million death reported globally. It is caused by physical or genetic factor. There are various targets for the inhibition of growth of cancerous cells. Inhibition of colchicines binding site of tubulin is promising target in field of cancer management. In this study, we designed 25 novel thiazole and triazolothiadiazine derivatives as colchicine binding site inhibitors and …

  Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 6, Issue 1, 2019 · pp. 10–20 Read article →