1 publication

• Published Subscription 28 Jun 2018

  2D-QSAR (Quantitative Structure Activity Relationship) Study of Probable Inhibitors for Oral and Cervical Cancers, Generation of Model for Pharmacophore Prediction

  By Krishna Misra, Ajay Kumar Singh

  Abstract: Twenty-four analogs, conjugates and congeners of curcumin reported as inhibitors against HPV 16 E6 and E7 protein targets have been selected for generating QSAR model. The 46 descriptors were calculated using Schrodinger program version quikprop 9.2. Two alternative methods have been used to generate QSAR models. The first model generation was built on 5 descriptors namely glob, QPlogS, CIQPlogS, IP (eV), human oral absorption which were subjected to multiple linear …

  Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 5, Issue 1, 2018 · pp. 1–13 Read article →