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Chitosan-Glycine Cross-Linked Microspheres for Controlled Release of IsoniazidBy K. C. Gupta, M NV Ravikumar, Fawzi Habeeb Jabrail
Abstract: Semi-interpenetrating polymer network microspheres of chitosan with glycine have been prepared for encapsulation and controlled release of isoniazid (INH) as a model drug. The method involved the exposure of microspheres to the vapor of cross-linking agent to effect the cross-linking under mild conditions. The swelling behavior, hydrolytic degradation and loading capacity of microspheres for INH have been investigated. The prepared microspheres have shown 96% drug loading capacity, which suggested that …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 6, Issue 3, 2015 · pp. 7–12 Read article →