11 publications
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Cryptosporidium parvum Mediated Diarrhea in Immunocompromised PatientsBy Durgadas N.
Abstract: Cryptosporidium parvum is one of the important diarrheal agents, especially in malnourished children and immunocompromised patients. Of the many species, Cryptosporidium parvum and Cryptosporidium hominis are the two major species that cause water borne outbreaks. The geographic difference in the distribution of parasite has been attributed to sources and its mode of transmission. The parasite is able to survive in the environment for long time and is resistant to many …
Published in Research and Reviews : A Journal of Immunology · Vol. 6, Issue 3, 2016 · pp. 5–9 Read article →
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Transmission, Immune Response, and Immunomodulation in GiardiasisBy Durgadas N.
Abstract: Giardiasis is a major public health problem at least in terms of morbidity in many geographical areas of the world. There are regional pockets in developing countries where prevalence rate of giardiasis is much higher than other parasitic diseases. The prevalence of Giardia intestinalis in symptomatic diarrhoeal cases vary from place to place and also from time to time. The overall prevalence generally ranges from 2 to 57% and mainly …
Published in Research and Reviews : A Journal of Immunology · Vol. 6, Issue 2, 2016 · pp. 13–19 Read article →
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Pathogenesis, Immune Response and Vaccine Development in AmoebiasisBy Durgadas N.
Abstract: Worldwide, approximately fifty million cases of invasive E histolytica disease occur each year and resulting in more than 100,000 deaths. It is the second leading cause of mortality due to a protozoan parasitic infection after malaria. Entamoeba histolytica infection is associated with considerable morbidity and mortality in the form of intestinal and extra-intestinal amoebiasis especially in developing countries. Recent molecular studies have conclusively proved that there are morphologically similar species …
Published in Research and Reviews : A Journal of Immunology · Vol. 5, Issue 3, 2015 · pp. 30–35 Read article →
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Necessity of Multiple Strategies to Combat and Eliminate RabiesBy Durgadas N.
Abstract: Rabies is a vaccine-preventable viral disease and is the deadliest of all human diseases. There is no cure or treatment for disease, but disease is preventable by post-exposure immunization. Rabies is a zoonotic disease and a number of animals are reservoirs. Dogs have historically been associated with rabies transmission to humans, but cats, bats also transmit rabies to humans. Globally, around 55,000 people die of rabies every year. Global estimate …
Published in Research and Reviews : A Journal of Immunology · Vol. 5, Issue 2, 2015 · pp. 17–20 Read article →
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Prevention of Breakthrough Varicella and Outbreaks by Two Dose VaccinationBy Durgadas N.
Abstract: Among viral infections, one of the known human herpes viruses, Varicella-Zoster Virus (VZV) causes latent infection. The VZV causes two distinct diseases, varicella (chickenpox) and after latency shingles (herpes zoster). Although safe and effective vaccine is available, it is not widely used in many geographic areas mainly because of non-inclusion in the routine immunization schedule. Over the years, many countries have reported more than 90% reduction in number of varicella …
Published in Research and Reviews : A Journal of Immunology · Vol. 4, Issue 3, 2014 · pp. 24–28 Read article →
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Mumps Outbreaks in Vaccinated PopulationBy Durgadas N.
Abstract: The available approved safe and effective vaccines have prevented millions of deaths. When compared to prevaccine era, more than 98% decrease has been recorded for many diseases like diphtheria, invasive Haemophilus influenzae, measles, rubella, rotavirus, and hepatitis A. Further, the successful global eradication of small pox and near-elimination of polio from most of the global regions underlines the importance of vaccination. The available literature on mumps reveals that it is …
Published in Research and Reviews : A Journal of Immunology · Vol. 4, Issue 2, 2014 · pp. 8–11 Read article →
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Human Papilloma Virus-mediated Carcinoma of CervixBy Mullai Chelvi Munusamy, Durgadas N.
Abstract: Cervical cancer is a major global health problem, with more than 500,000 new cases being reported each year and an estimated 275,000 women dying from it annually. One of the important causes of this cancer is human papilloma virus (HPV). Of the several types of HPV, type 16 and 18 are considered to be the main types that mediate the development of cervix carcinoma. The high-risk types cause not only …
Published in Research and Reviews : A Journal of Immunology · Vol. 3, Issue 2, 2013 · pp. 11–14 Read article →
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Monoclonal Antibody (mAb) Drugs in Cancer TherapyBy Durgadas N.
Abstract: Monoclonal antibodies (mAb) are widely used in the diagnosis of diseases, detection of marker molecules and in therapy. The mAb drugs are increasingly used to treat hypersensitivity, autoimmune diseases, transplantation rejection and more importantly in cancer therapy. Although the application of mAbs in the treatment of infectious diseases is limited, the wide acceptance of these drugs in cancer therapy is remarkable. As of 2011, at least 11 FAB approved mAb …
Published in Research and Reviews : A Journal of Immunology · Vol. 2, Issue 2, 2012 · pp. 6–10 Read article →
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Measles Eradication by Vaccination: Opportunities and ChallengesBy Durgadas N.
Abstract: Measles is one of the vaccine preventable viral diseases that mainly occur in children. The disease was targeted for elimination by a vaccination program that was initiated three decades back. The measles death rate decreased by 74% from the year 2000 to 2010. This was short of targeted 90% mainly because of low vaccine coverage in some countries. Although, there is marked reduction in measles morbidity and mortality, still it …
Published in Research and Reviews : A Journal of Immunology · Vol. 2, Issue 3, 2012 · pp. 1–7 Read article →
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Control of Rubella Infection and Elimination of Congenital Rubella Syndrome by Surveillance and VaccinationBy Durgadas N.
Abstract: Of the vaccine preventable child hood diseases, diphtheria, measles, tetanus, polio are controlled by effective vaccination program. The same is not true about rubella virus. Rubella virus is known to cause mild illness, but the virus when infects women in early pregnancy or just before conception can lead to the development of congenital rubella syndrome (CRS) in fetus or newborn. In America and European region, the CRS is virtually eliminated …
Published in Research and Reviews : A Journal of Immunology · Vol. 2, Issue 1, 2012 · pp. 27–33 Read article →
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Vaccination as a Prevention Strategy to Control Rotavirus Gastroenteritis in ChildrenBy Durgadas N.
Abstract: Among the viral causes of gastroenteritis, rotavirus is the leading cause of morbidity and mortality in children of less than 5 years. Globally, every year, it accounts for more than 500,000 deaths. The main mode of transmission is by faecal-oral route. Although in most of the children, the Rotavirus infection remains asymptomatic, in some leads to acute diarrhoea and severe dehydration. Moreover, malnutrition contributes to the severity of disease and …
Published in Research and Reviews : A Journal of Immunology · Vol. 1, Issue 1-3, 2011 · pp. 27–32 Read article →