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Effect of Chronic Inescapable Footshock and Antidepressant Treatment on BDNF/TrkB Levels in Rat HippocampusBy Ritabrata Banerjee, Anup K. Ghosh, Balaram Ghosh, Amal C. Mondal
Abstract: Depression is a major health problem globally. Chronic stress arising out of life style or social factors may trigger depression, the molecular basis of which has been attributed to alterations of brain chemicals like neurotrophins. Among these neurotrophins, brain-derived neurotrophic factor regulates many physiological functions in the brain, alteration of which has been well associated with the pathogenesis of depression. Stress-induced helplessness in rodents constitutes a well-defined model to investigate …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 2, Issue 2, 2012 · pp. 12–21 Read article →