Spatial metabolomics
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The Cellular Architecture of Feed Efficiency: Can Single-Cell Multi-Omics, Spatial Metabolomics, and Nutrient-Flux Mapping Reveal Hidden Metabolic Specialization across Intestinal, Hepatic, and Skeletal-Muscle Cell Populations in Poultry?
Abstract: Feed efficiency in poultry emerges from complex interactions among nutrient absorption, metabolic transformation, cellular energy expenditure, and productive tissue accretion. However, conventional whole-organ and bulk-tissue approaches inadequately capture the cellular heterogeneity underlying nutrient utilization and metabolic efficiency. This review proposes a cell-resolved framework integrating single-cell multi-omics, spatial metabolomics, and stable-isotope nutrient-flux mapping to elucidate hidden metabolic specialization across intestinal, hepatic, and skeletal-muscle cell populations. Particular emphasis is placed on intestinal …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 4, Issue 2, 2026 Read article