Delivery system

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• Published Subscription Original Research 1 Jul 2026

  Gastro Retentive Drug Target System: Its Needs, Advantages, Limitation and Approaches

  By Shyam Parbata, Sneha Ghodkeb, Pranjal Chougule, Anuja Nirwane, Nilesh Chougule

  Abstract: Background: Gastro retentive drug delivery systems (GRDDS) address limitations of oral therapy for drugs with poor solubility, instability at intestinal pH, or narrow absorption windows by prolonging gastric residence and increasing contact with the gastric mucosa. Objectives: To review GRDDS approaches—floating systems, mucoadhesive systems, and super porous hydrogels—with emphasis on formulation strategies and polymer–excipient selection to enhance gastric retention, modulate buoyancy/swelling/adhesion, and ultimately improve oral bioavailability and therapeutic outcomes for …

  Published in Trends in Drug Delivery · Vol. 13, Issue 2, 2026 Read article →